"LATS2" Related Products

Recombinant Human LATS2, GST-tagged

Cat. No. : LATS2-381H
Product Overview : Recombinant human LATS2 (480-1088) was expressed bybaculovirusinSf9 insect cellsusing an N-terminal GST tag. MW = 98 kDa.
Description : LATS2 is a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The kinase activity and two conserved domains within LATS2 are responsible for the suppression of tumorigenicity and inhibition of cell growth. LATS2 negatively regulates the cell cycle by controlling G1/S and/or G2/M transition. LATS2 interacts with the centrosomal proteins AURORA A and Ajuba and is required for accumulation of γ-tubulin and spindle formation at the onset of mitosis. LATS2 also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. LATS2 can also function as a co-repressor of androgen-responsive gene expression.
Source : Sf9 insect cells using baculovirus.
Sequence : 480-1088.
Applications : Western Blot.
Storage And Stability : Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) [ Homo sapiens ]
Synonyms : LATS, large tumor suppressor, homolog 2 (Drosophila); KPM; FLJ13161; LATS2; LATS, large tumor suppressor, homolog 2; warts-like kinase; serine/threonine kinase KPM; kinase phosphorylated during mitosis protein; LATS (large tumor suppressor, Drosophila) homolog 2; EC 2.7.11.1; OTTHUMP00000018106; Kinase phosphorylated during mitosis protein; Large tumor suppressor homolog 2; Serine/threonine-protein kinase kpm; Warts-like kinase
Gene ID : 26524
mRNA Refseq : NM_014572
Protein Refseq : NP_055387
MIM : 604861
UniProt ID : Q9NRM7
Chromosome Location : 13q11-q12
Function : ATP binding; magnesium ion binding; nucleotide binding; protein serine/threonine kinase activity; transferase activity

Online Inquiry

Note: There will be extra charge for optional service!

Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information

Optional requirements on this protein    +Expand

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.