"ADRB2" Related Products


Recombinant Human GNB1

Cat.No.: ADRB2-31550TH
Product Overview: Recombinant full length Human ADBR2 with N terminal FLAG tag and C terminal His tag, fused with Giα2 co-expressed with β 1 and γ 2 in Sf9 insect cells.
Description: This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes.
Conjugation: FLAG,His
Biological activity: Activity:3.5-7.7 pmol/mg.
Form: Liquid
Storage buffer: Preservative: NoneConstituents: 75mM Tris HCl, 12.5mM Magnesium chloride, 1mM EDTA, pH 7.4
Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Gene Name: ADRB2 adrenergic, beta-2-, receptor, surface [ Homo sapiens ]
Official Symbol: ADRB2
Synonyms: ADRB2; adrenergic, beta-2-, receptor, surface; ADRB2R; beta-2 adrenergic receptor; ADRBR; B2AR; BAR;
Gene ID: 154
mRNA Refseq: NM_000024
Protein Refseq: NP_000015
Uniprot ID: P07550
Chromosome Location: 5q31-q32
Pathway: Adrenoceptors, organism-specific biosystem; Amine ligand-binding receptors, organism-specific biosystem; Arf6 signaling events, organism-specific biosystem; Arf6 trafficking events, organism-specific biosystem; Calcium Regulation in the Cardiac Cell, organism-specific biosystem;
Function: G-protein coupled receptor activity; adenylate cyclase binding; adrenergic receptor activity; beta2-adrenergic receptor activity; dopamine binding;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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