Recombinant Human ANG

• Cat.No.: ANG-27314TH
• Product Overview: Recombinant full length Human Angiogenin with an N terminal proprietary tag; predicted mwt: 39.64 kDa inclusive of tag.

Specification

• Description: The protein encoded by this gene is an exceedingly potent mediator of new blood vessel formation. It hydrolyzes cellular tRNAs resulting in decreased protein synthesis and is similar to pancreatic ribonuclease. Alternative splicing results in two transcript variants encoding the same protein. This gene and the gene that encodes ribonuclease, RNase A family, 4 share promoters and 5 exons. Each gene splices to a unique downstream exon that contains its complete coding region.
• Protein length: 123 amino acids
• Molecular Weight: 39.640kDa inclusive of tags
• Source: Wheat germ
• Tissue specificity: Expressed predominantly in the liver. Also detected in endothelial cells and spinal cord neurons.
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: QDNSRYTHFLTQHYDAKPQGRDDRYCESIMRRRGLTSPCK DINTFIHGNKRSIKAICENKNGNPHRENLRISKSSFQVTT CKLHGGSPWPPCQYRATAGFRNVVVACENGLPVHLDQSIF RRP
• Sequence Similarities: Belongs to the pancreatic ribonuclease family.

Gene Information

• Gene Name: ANG angiogenin, ribonuclease, RNase A family, 5 [ Homo sapiens ]
• Official Symbol: ANG
• Synonyms: ANG; angiogenin, ribonuclease, RNase A family, 5; angiogenin; RNASE5
• Gene ID: 283
• mRNA Refseq: NM_001097577
• Protein Refseq: NP_001091046
• MIM: 105850
• Uniprot ID: P03950
• Chromosome Location: 14q11.1-q11.2
• Function: DNA binding; actin binding; copper ion binding; endonuclease activity; heparin binding