Native Human APOC3

• Cat.No.: APOC3-27333TH
• Product Overview: Full length native Apolipoprotein CIII purified from human plasma, VLDL.

Specification

• Description: Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein.APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles.The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes.The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed.An increase in ap°C-III levels induces the development of hypertriglyceridemia.
• Form: Lyophilised:Reconstitute with 59.9ul distilled water.
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 10mM Ammonium bicarbonate, pH 7.4
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

Gene Information

• Gene Name: APOC3 apolipoprotein C-III [ Homo sapiens ]
• Official Symbol: APOC3
• Synonyms: APOC3; apolipoprotein C-III
• Gene ID: 345
• mRNA Refseq: NM_000040
• Protein Refseq: NP_000031
• MIM: 107720
• Uniprot ID: P02656
• Chromosome Location: 11q23-qter
• Pathway: Chylomicron-mediated lipid transport, organism-specific biosystem; HDL-mediated lipid transport, organism-specific biosystem; Lipid digestion, mobilization, and transport, organism-specific biosystem; Lipoprotein metabolism, organism-specific biosystem; Metabolism of lipids and lipoproteins, organism-specific biosystem
• Function: cholesterol binding; enzyme regulator activity; high-density lipoprotein particle receptor binding; lipase inhibitor activity; phospholipid binding