"Il12a" Related Products


Recombinant Murine Interleukin 12a, P35-P40

Cat. No. : Il12a-211M
Product Overview : Recombinant Murine IL-12 is a disulfide linked heterodimeric protein with a molecular weight of 75 kDa comprised of disulfide-bonded 35 kDA (p35) and 40 kDa (p40) subunits. It is expressed inCHO cells.
Description : Interleukin 12 (IL-12) is a regulatory protein produced by activated B lymphocytes and macrophages. The biological activities of IL-12 include the stimulation of growth of activated CD4+ and CD8+ T cells and NK cells. Human IL-12 also promotes the development of proinflammatory/TH1-like CD4+ cells and cytotoxic CD8+T cells.
Source : CHO cells.
Purity : Greater than 98% (determined by SDS-PAGE and HPLC analysis).
Specific Activity : ≥ 1 x10⁷ IU/mg.
Endotoxin Level : < 0.1 ng per µg of rMu IL-12 (1EU/µg).
Biological Activity : The ED₅₀ as determined by the dose-dependent stimulation of INF-( production by murine splenocytes co-stimulated with IL-18 is ≤ 0.1 ng / ml, corresponding to a specific activity of ≥ 1 x10⁷ units/mg.
Formulation : Lyophilized from a sterile-filtered protein solution in 0.5 x PBS (pH 7.2).
Reconstitution : Please Note: Always centrifuge product before opening vial. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. This solution can than be diluted into other aqueous buffers and stored at -20°C for future use.
Storage : The lyophilized protein, though stable at room temperature for up to 3 weeks, is best stored desiccated at -20°C. Reconstituted murine IL-12 should be used immediately or stored long-term in undiluted working aliquots at -20°C. Avoid repeated freeze / thaw cycles.
PDB rendering based on 1f45. :

Gene Name : Il12a interleukin 12a [ Mus musculus ]
Synonyms : Il12a; interleukin 12a; p35; Ll12a; Il-12a; IL-12p35; MGC151228; MGC151232; interleukin 12a p35 subunit; interleukin 12a
Gene ID : 16159
mRNA Refseq : NM_001159424
Protein Refseq : NP_001152896
UniProt ID : P43431
Chromosome Location : 3 E1; 3 37.0 cM
Pathway : Allograft rejection; Cytokine-cytokine receptor interaction; RIG-I-like receptor signaling pathway; Jak-STAT signaling pathway; Toll-like receptor signaling pathway; Type I diabetes mellitus
Function : cytokine activity; growth factor activity; interleukin-12 beta subunit binding; interleukin-12 receptor binding

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