Recombinant Human Stratifin, GST-tagged
Cat.No. : |
SFN-1421H |
Product Overview : |
Recombinant human full-length 14-3-3sigma was expressed inE. colicells using a N-terminal GST tag. MW=51kDa. |
- Specification
- Gene Information
- Related Products
Cat. No. : |
SFN-1421H |
Description : |
14-3-3σ or stratifin is a protein that is strongly induced by gamma irradiation and other DNA-damaging agents. The induction of 14-3-3σ is mediated by a p53 responsive element. Exogenous introduction of 14-3-3σ into cycling cells results in a G2 cell cycle arrest. Knockout of 14-3-3σ in cells showed that the cells are unable to maintain cell cycle arrest after DNA damage. The 14-3-3σ -/- cells die as they enter mitosis. This process is associated with a failure of the 14-3-3σ -deficient cells to sequester the proteins that initiate mitosis and prevent them from entering the nucleus. Thus, 14-3-3σ plays an important role in maintaining the G2 checkpoint in cells and preventing mitotic death. |
Source : |
E. coli. |
Sequence : |
Full-length. |
Applications : |
Western Blot. |
Storage And Stability : |
Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Gene Name : |
SFN stratifin [ Homo sapiens ] |
Synonyms : |
SFN; stratifin; YWHAS; 14-3-3 sigma; 14-3-3 protein sigma; Stratifin; Epithelial cell marker protein 1 |
Gene ID : |
2810 |
mRNA Refseq : |
NM_006142 |
Protein Refseq : |
NP_006133 |
UniProt ID : |
P31947 |
Chromosome Location : |
1p36.11 |
MIM : |
601290 |
Pathway : |
Cell Cycle; p53 signaling pathway |
Function : |
protein kinase C inhibitor activity; protein domain specific binding |
Products Types
Related Gene
SFN
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.