Recombinant Human Activating Transcription Factor 1, GST-tagged ATF1-1431H

Recombinant Human Activating Transcription Factor 1, GST-tagged

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Recombinant Human Activating Transcription Factor 1, GST-tagged

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Cat. No. : ATF1-1431H
Product Overview : Recombinant human full-length ATF1 was expressed inSf9 insect cellsusing a N-terminal GST tag. MW=63kDa.
Description : ATF1 is a class of transcription factor that stimulates gene expression of several cell growth-related genes through protein kinase A-related cAMP response elements. ATF1 can physically associate with BRCA1 in vitro, in yeast, and in human cells and BRCA1 is implicated in the transcriptional activation of ATF1 target genes, some of which are involved in the transcriptional response to DNA damage. Mitogen- and stress-activated protein kinase 1 (MSK1) and MSK2 play a role in the stress-induced phosphorylation of ATF1 in primary embryonic fibroblasts. However, mitogen-induced phosphorylation of ATF1 is greatly reduced.
Source : Sf9 insect cells using baculovirus.
Sequence : Full-length.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
PDB rendering based on 1dh3. :

Gene Name : ATF1 activating transcription factor 1 [ Homo sapiens ]
Synonyms : ATF1; activating transcription factor 1; TREB36; EWS-ATF1; FUS/ATF-1; Cyclic AMP-dependent transcription factor ATF-1; cAMP-dependent transcription factor ATF-1; Activating transcription factor 1; Protein TREB36
Gene ID : 466
mRNA Refseq : NM_005171
Protein Refseq : NP_005162
UniProt ID : AAB25878
Chromosome Location : 12q13
MIM : 123803
Pathway : Signalling by NGF
Function : protein dimerization activity; sequence-specific DNA binding; transcription factor activity

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