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Recombinant Human ATF1

Cat.No.: ATF1-27042TH
Product Overview: Recombinant fusion protein, full length human ATF1 expressed by baculovirus in Sf9 insect cells using a N-terminal proprietary tag.
Description: This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6.
Form: Liquid
Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM PMSF, pH 7.5
Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities: Belongs to the bZIP family. ATF subfamily.Contains 1 bZIP domain.Contains 1 KID (kinase-inducible) domain.
Gene Name: ATF1 activating transcription factor 1 [ Homo sapiens ]
Official Symbol: ATF1
Synonyms: ATF1; activating transcription factor 1; cyclic AMP-dependent transcription factor ATF-1; TREB36;
Gene ID: 466
mRNA Refseq: NM_005171
Protein Refseq: NP_005162
MIM: 123803
Uniprot ID: P18846
Chromosome Location: 12q13
Pathway: Activated TLR4 signalling, organism-specific biosystem; CREB phosphorylation, organism-specific biosystem; EGFR1 Signaling Pathway, organism-specific biosystem; ErbB1 downstream signaling, organism-specific biosystem; HTLV-I infection, organism-specific biosystem;
Function: protein complex binding; protein heterodimerization activity; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; sequence-specific distal enhancer binding RNA polymerase II transcription factor activity;

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