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Recombinant Human Breakpoint Cluster Region,GST-tagged

Cat. No.: BCR-1436H
Product Overview: Recombinant human BCR (1-695) was expressed by baculovirus inSf9insect cellsusing an N-terminal GST tag. MW = 120kDa.
Description: BCR (also known as breakpoint cluster region) encodes a phosphoprotein that has serine/threonine kinase activity. The human c-ABL oncogene is translocated from chromosome 9 to a region on chromosome 22 (associated with BCR) in chronic myelocytic leukemia. In classical t(9;22) translocation, as observed in chronic granulocytic leukemia (CGL), a hybrid DNA unit is produced comprising the BCR gene product plus the translocated c-ABL gene from chromosome 9. The BCR-ABL hybrid protein (p210) is formed that displays increased tyrosine kinase activity. A similar DNA rearrangement of the p210 protein is also found in cases of Philadelphia-positive acute lymphoblastic leukemia (ALL).
Source: Sf9 insect cells using baculovirus.
Sequence: 1-695.
Applications: Western Blot.
Storage And Stability: Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name: BCR breakpoint cluster region [ Homo sapiens ]
Synonyms: BCR; breakpoint cluster region; ALL; CML; PHL; BCR1; D22S11; D22S662; FLJ16453
Gene ID: 613
mRNA Refseq: NM_004327
Protein Refseq: NP_004318
MIM: 151410
UniProt ID: P11274
Chromosome Location: 22q11; 22q11.23
Pathway: Chronic myeloid leukemia; Pathways in cancer; Signaling by Rho GTPases
Function: ATP binding; GTPase activator activity; Rho guanyl-nucleotide exchange factor activity; guanyl-nucleotide exchange factor activity; kinase activity; nucleotide binding; protein serine/threonine kinase activity; transferase activity

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