Recombinant Human AURKC

• Cat.No.: AURKC-27499TH
• Product Overview: Recombinant full length IPL-1/STK13/Aurora C protein (Human), MW ~61 kDa with N terminal enzyme tag, expressed by baculovirus in Sf9 insect cells.

Specification

• Description: This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants.
• Tissue specificity: Isoform 1 and isoform 2 are expressed in testis. Elevated expression levels were seen only in a subset of cancer cells such as HepG2, HuH7 and HeLa cells. Expression is maximum at M phase.
• Biological activity: Specific activity 65nmol/min/mg
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.Contains 1 protein kinase domain.

Gene Information

• Gene Name: AURKC aurora kinase C [ Homo sapiens ]
• Official Symbol: AURKC
• Synonyms: AURKC; aurora kinase C; serine/threonine kinase 13 (aurora/IPL1 like) , STK13; ARK3; AurC
• Gene ID: 6795
• mRNA Refseq: NM_001015878
• Protein Refseq: NP_001015878
• MIM: 603495
• Uniprot ID: Q9UQB9
• Chromosome Location: 19q13.3-qter
• Pathway: Aurora B signaling, organism-specific biosystem; Aurora C signaling, organism-specific biosystem; Signaling by Aurora kinases, organism-specific biosystem
• Function: ATP binding; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity