Native Human AZU1

• Cat.No.: AZU1-26565TH
• Product Overview: Full length native Human Azurocidin purified from Human neutrophils; amino acid 27-248, 222 amino acids, MWt 37kDa.

Specification

• Description: Azurophil granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the killing of microorganisms. The protein encoded by this gene is an azurophil granule antibiotic protein, with monocyte chemotactic and antibacterial activity. It is also an important multifunctional inflammatory mediator. This encoded protein is a member of the serine protease gene family but it is not a serine proteinase, because the active site serine and histidine residues are replaced. The genes encoding this protein, neutrophil elastase 2, and proteinase 3 are in a cluster located at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation.
• Source: Human neutrophils
• Species: Human
• Form: Lyophilised
• Molecular Mass: 37kDa
• Protein length: 222 amino acids
• Purity: >95% by SDS-PAGE
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
• Storage Buffer: De-ionized H2O

Gene Information

• Gene Name: AZU1 azurocidin 1 [ Homo sapiens ]
• Official Symbol: AZU1
• Synonyms: AZU1; azurocidin 1; azurocidin; AZAMP; AZU; CAP37; cationic antimicrobial protein 37; HBP; heparin binding protein; HUMAZUR; NAZC; neutrophil azurocidin; heparin-binding protein; cationic antimicrobial protein CAP37
• Gene ID: 566
• mRNA Refseq: NM_001700
• Protein Refseq: NP_001691
• MIM: 162815
• UniProt ID: P20160
• Chromosome Location: 19p13.3
• Function: catalytic activity; heparin binding; serine-type endopeptidase activity; toxin binding