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| Cat. No.: | Creb1-1443R |
| Product Overview: | Recombinant rat CREB1 (1-280) was expressed inE. colicells using a N-terminal GST tag. MW = 59 kDa. |
| Description: | CREB1 is a member of the cAMP responsive element binding protein family of transcription factors that are critical mediators of gene expression in response to extracellular signals and are essential regulators of adaptive behavior and long-term memory formation. Activation of CREB1 by protein kinase A-mediated phosphorylation has been implicated in the survival of mammalian cells. Mice lacking CREB in the central nervous system during development show extensive apoptosis of postmitotic neurons. CREB binds as homo- and heterodimers to promoters containing CRE and activator protein 1 (AP-1) sites to alter target-gene expression). |
| Source: | E. coli. |
| Sequence: | 1-280. |
| Applications: | Kinase Assay, Western Blot. |
| Storage And Stability: | Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
| Gene Name: | Creb1 cAMP responsive element binding protein 1 [ Rattus norvegicus ] |
| Synonyms: | Creb1; cAMP responsive element binding protein 1; Creb; Y protein; cAMP response element binding protein 1 |
| Gene ID: | 81646 |
| mRNA Refseq: | NM_031017 |
| Protein Refseq: | NP_112279 |
| UniProt ID: | P15337 |
| Chromosome Location: | 9q32 |
| Pathway: | Antigen processing and presentation; Huntington"s disease; Melanogenesis; Prostate cancer |
| Function: | DNA binding; RNA polymerase II transcription factor activity, enhancer binding; double-stranded DNA binding IDA PubMed protein binding; sequence-specific DNA binding; specific RNA polymerase II transcription factor activity; transcription factor activity |
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