Recombinant Human BMPR1B

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Recombinant Human BMPR1B

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Cat.No. : BMPR1B-26757TH
Product Overview : Recombinant fragment corresponding to amino acids 149-502 of Human BMPR1B with an N terminal proprietary tag; MWt 68kDa.
Description : This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension.
Protein length : 354 amino acids
Molecular Weight : 68.000kDa inclusive of tags
Source : Baculovirus infected sf9 cells
Biological activity : The Specific activity of BMPR1B-26757TH was determined to be 23 nmol/min/mg.
Form : Liquid
Purity : by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities : Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.Contains 1 GS domain.Contains 1 protein kinase domain.
Gene Name : BMPR1B bone morphogenetic protein receptor, type IB [ Homo sapiens ]
Official Symbol : BMPR1B
Synonyms : BMPR1B; bone morphogenetic protein receptor, type IB; bone morphogenetic protein receptor type-1B; ALK6; CDw293;
Gene ID : 658
mRNA Refseq : NM_001203
Protein Refseq : NP_001194
MIM : 603248
Uniprot ID : O00238
Chromosome Location : 4q23-q24
Pathway : Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Ovarian Infertility Genes, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signaling by BMP, organism-specific biosystem;
Function : ATP binding; SMAD binding; activin receptor activity, type II; metal ion binding; nucleotide binding;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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