Recombinant Human BRAF
Cat.No. : | BRAF-26566TH |
Product Overview : | Recombinant fragment corresponding to amino acids 416-766 of Human B Raf, containing a V599E mutation, with an N terminal proprietary tag, expressed by Baculovirus in Sf9 insect cells, MWt 63 kDa. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene. |
Tissue specificity : | Brain and testis. |
Biological activity : | The specific activity of BRAF-26566TH was determined to be 98 nmol/min/mg. |
Form : | Liquid |
Storage buffer : | Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5 |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequence Similarities : | Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.Contains 1 phorbol-ester/DAG-type zinc finger.Contains 1 protein kinase domain.Contains 1 RBD (Ras-binding) domain. |
Gene Name : | BRAF v-raf murine sarcoma viral oncogene homolog B1 [ Homo sapiens ] |
Official Symbol : | BRAF |
Synonyms : | BRAF; v-raf murine sarcoma viral oncogene homolog B1; serine/threonine-protein kinase B-raf; BRAF1; |
Gene ID : | 673 |
mRNA Refseq : | NM_004333 |
Protein Refseq : | NP_004324 |
MIM : | 164757 |
Uniprot ID : | P15056 |
Chromosome Location : | 7q34 |
Pathway : | ARMS-mediated activation, organism-specific biosystem; Activation of NMDA receptor upon glutamate binding and postsynaptic events, organism-specific biosystem; Acute myeloid leukemia, organism-specific biosystem; Acute myeloid leukemia, conserved biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; |
Function : | ATP binding; MAP kinase kinase kinase activity; metal ion binding; mitogen-activated protein kinase kinase binding; nucleotide binding; |
Products Types
◆ Recombinant Protein | ||
BRAF-2781H | Recombinant Human BRAF Protein, His-tagged, BSA Conjugated | +Inquiry |
BRAF-1081M | Recombinant Mouse BRAF Protein, His (Fc)-Avi-tagged | +Inquiry |
BRAF-328H | Recombinant Human BRAF Protein, His-tagged | +Inquiry |
BRAF-456H | Recombinant Human BRAF Protein, His (Fc)-Avi-tagged | +Inquiry |
Braf-441M | Recombinant Mouse Braf Protein, MYC/DDK-tagged | +Inquiry |
◆ Lysates | ||
BRAF-8414HCL | Recombinant Human BRAF 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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