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Recombinant Human CALCR

Cat.No. : CALCR-27793TH
Product Overview : Recombinant fragment: CNNEVQTTVK RQWAQFKIQW NQRWGRRPSN RSARAAAAAA EAGDIPIYIC HQELRNEPAN NQGEESAEII PLNIIEQESS A corresponding to amino acids 394-474 of Human Calcitonin receptor with an N terminal proprietary tag; Predicted MWt 34.54 kDa.
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Description : This gene encodes a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis. Alternate splicing results in multiple transcript variants.
Protein length : 81 amino acids
Molecular Weight : 34.540kDa inclusive of tags
Source : Wheat germ
Form : Liquid
Purity : Proprietary Purification
Storage buffer : pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids : CNNEVQTTVKRQWAQFKIQWNQRWG RRPSNRSARAAAAAAEAGDIPIYIC HQELRNEPANNQGEESAEIIPLNII EQESSA
Sequence Similarities : Belongs to the G-protein coupled receptor 2 family.
Gene Name : CALCR calcitonin receptor [ Homo sapiens ]
Official Symbol : CALCR
Synonyms : CALCR; calcitonin receptor; CTR;
Gene ID : 799
mRNA Refseq : NM_001164737
Protein Refseq : NP_001158209
MIM : 114131
Uniprot ID : P30988
Chromosome Location : 7q21.3
Pathway : Calcitonin-like ligand receptors, organism-specific biosystem; Class B/2 (Secretin family receptors), organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem;
Function : calcitonin binding; NOT calcitonin binding; calcitonin binding; calcitonin receptor activity; calcitonin receptor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What is the relationship between CALCR and medullary thyroid carcinoma (MTC), and how is CALCR used as a diagnostic marker for MTC? 08/21/2021

CALCR is expressed in MTC cells. Measuring CALCR expression can serve as a diagnostic marker for MTC, helping to identify and diagnose this type of thyroid cancer.

How does the CALCR receptor relate to the action of calcitonin and its effect on bone health? 05/04/2020

The CALCR receptor is the target for calcitonin. When calcitonin binds to CALCR on osteoclasts, it inhibits bone resorption, helping to maintain bone health.

How does the CALCR receptor differ from other G-protein-coupled receptors, and what are its downstream signaling pathways? 03/02/2019

CALCR is specific to calcitonin signaling. Downstream signaling pathways include activation of G proteins, which affect intracellular calcium levels and other signaling molecules.

How does the CALCR receptor impact bone metabolism and calcium regulation? 10/30/2018

CALCR activation in osteoclasts inhibits bone resorption, which plays a crucial role in maintaining calcium homeostasis by reducing calcium release from bone.

What role does the CALCR receptor play in the treatment of osteoporosis and other bone-related conditions? 02/16/2018

CALCR activation by calcitonin has been used in the treatment of osteoporosis to inhibit bone resorption, thus helping to maintain bone density.

Customer Reviews (3)

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Reviews
04/14/2022

    It's clear that the product is meticulously crafted for laboratory use.

    02/15/2022

      My experiments rely on the consistency of the product, and it hasn't let me down.

      12/25/2019

        The product exceeded my expectations in terms of quality and performance.

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