Recombinant Human CALD1

• Cat.No.: CALD1-26059TH
• Product Overview: Recombinant full length protein, corresponding to amino acids 1-538 of Human Caldesmon, with an N-terminal proprietary tag, predicted MWt 85.25 kDa

Specification

• Description: This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.
• Protein length: 538 amino acids
• Molecular Weight: 85.250kDa inclusive of tags
• Source: Wheat germ
• Tissue specificity: High-molecular-weight caldesmon (isoform 1) is predominantly expressed in smooth muscles, whereas low-molecular-weight caldesmon (isoforms 2, 3, 4 and 5) are widely distributed in non-muscle tissues and cells. Not expressed in skeletal muscle or heart.
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the caldesmon family.

Gene Information

• Gene Name: CALD1 caldesmon 1 [ Homo sapiens ]
• Official Symbol: CALD1
• Synonyms: CALD1; caldesmon 1; caldesmon; CDM; H CAD; L CAD
• Gene ID: 800
• mRNA Refseq: NM_004342
• Protein Refseq: NP_004333
• MIM: 114213
• Uniprot ID: Q05682
• Chromosome Location: 7q33
• Pathway: Muscle contraction, organism-specific biosystem; Myometrial Relaxation and Contraction Pathways, organism-specific biosystem; Smooth Muscle Contraction, organism-specific biosystem; Vascular smooth muscle contraction, organism-specific biosystem; Vascular smooth muscle contraction, conserved biosystem
• Function: actin binding; calmodulin binding; myosin binding; tropomyosin binding