Recombinant Human CAPN3 Protein, GST-tagged

• Cat.No.: CAPN3-27209TH
• Product Overview: Recombinant Human CAPN3(1 a.a. - 309 a.a.) fused with GST tag at N-terminal was expressed in Wheat Germ.

Specification

• Description: Calpain, a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well established. This gene encodes a muscle-specific member of the calpain large subunit family that specifically binds to titin. Mutations in this gene are associated with limb-girdle muscular dystrophies type 2A. Alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms and some variants are ubiquitously expressed.
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Form: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
• Molecular Mass: 59.62 kDa
• AA Sequence: MHGNKQHLQKDFFLYNASKARSKTY INMREVSQRFRLPPSEYVIVPSTYE PHQEGEFILRVFSEKRNLSEEVENT ISVDRPVKKKKTKPIIFVSDRANSN KELGVDQESEEGKGKTSPDKQKQSP QPQPGSSDQESEEQQQFRNIFKQIA GDDMEICADELKKVLNTVVNKHKDL KTHGFTLESCRSMIALMDTDGSGKL NLQEFHHLWNKIKAWQKIFKHYDTD QSGTINSYEMRNAVNDAGFHLNNQL YDIITMRYADKHMNIDFDSFICCFV RLEGMFRAFHAFDKDGDGIIKLNVL EWLQLTMYA
• Applications: Enzyme-linked Immunoabsorbent; Assay Western Blot (Recombinant protein); Antibody Production; Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.

Gene Information

• Gene Name: CAPN3 calpain 3, (p94) [ Homo sapiens ]
• Official Symbol: CAPN3
• Synonyms: CAPN3; calpain 3, (p94); LGMD2, LGMD2A; calpain-3; CANP3; nCL 1; p94; calpain L3; new calpain 1; calpain, large polypeptide L3; calcium-activated neutral proteinase 3; calpain p94, large [catalytic] subunit; muscle-specific calcium-activated neutral protease 3 large subunit; LGMD2; nCL-1; CANPL3; LGMD2A; MGC4403; MGC10767; MGC11121; MGC14344
• Gene ID: 825
• mRNA Refseq: NM_000070
• Protein Refseq: NP_000061
• MIM: 114240
• UniProt ID: P20807