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Recombinant Human CBL

Cat.No.: CBL-26493TH
Product Overview: Recombinant fragment of Human CBL protein with an N terminal proprietary tag; predicted mwt: 36.63 kDa inclusive of tag.
Description: The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation.
Protein length: 100 amino acids
Molecular Weight: 36.630kDa inclusive of tags
Source: Wheat germ
Form: Liquid
Purity: Proprietary Purification
Storage buffer: pH: 8.00Constituents:0.79% Tris HCl, 0.3% Glutathione
Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids: NIQSQAPSITESSTFGEGNLAAAHANTGPEESENEDDGYDVPKPPVPAVLARRTLSDISNASSSFGWLSLDGDPTTNVTEGSQVPERPPKPFPRRINSER
Sequence Similarities: Contains 1 Cbl-PTB (Cbl-type phosphotyrosine-binding) domain.Contains 1 RING-type zinc finger.Contains 1 UBA domain.
Gene Name: CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence [ Homo sapiens ]
Official Symbol: CBL
Synonyms: CBL; Cas-Br-M (murine) ecotropic retroviral transforming sequence; CBL2; E3 ubiquitin-protein ligase CBL; c Cbl; oncogene CBL2; RNF55;
Gene ID: 867
mRNA Refseq: NM_005188
Protein Refseq: NP_005179
MIM: 165360
Uniprot ID: P22681
Chromosome Location: 11q23.3-qter
Pathway: B Cell Receptor Signaling Pathway, organism-specific biosystem; Bacterial invasion of epithelial cells, organism-specific biosystem; Bacterial invasion of epithelial cells, conserved biosystem; CDC42 signaling events, organism-specific biosystem; Chronic myeloid leukemia, organism-specific biosystem;
Function: SH3 domain binding; calcium ion binding; ephrin receptor binding; ligase activity; phosphotyrosine binding;

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