"CDKN1B" Related Products


Recombinant Human CDKN1B, GST-tagged

Cat. No. : CDKN1B-1478H
Product Overview : Recombinant full-length human p27KIP1 was expressed inE. colicells using a N-terminal GST tag. MW = 52 kDa.
Description : KIP1 (cyclin-dependent kinase inhibitor 1B) is a kinesin-related motor protein required for mitotic spindle assembly and chromosome segregation. Many tumorigenic processes modulate cell-cycle progression by regulating the levels of the cyclin-dependent kinase inhibitor KIP1. KIP1 binds to and inhibits cyclinE-Cdk2 complex, cyclinA-CDK2 and cyclinD1-CDK4. The phosphorylation- and ubiquitination-dependent proteolysis of KIP1 is implicated in control of the G1-S transition in the cell cycle. KIP1 is critical for retinoblastoma protein (Rb)-induced cellular proliferative senescence.
Source : E. coli.
Sequence : Full-length
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) [ Homo sapiens ]
Synonyms : CDKN1B; cyclin-dependent kinase inhibitor 1B (p27, Kip1); KIP1; MEN4; CDKN4; MEN1B; P27KIP1; cyclin -dependent kinase inhibitor 1B; p27Kip1; Cyclin-dependent kinase inhibitor p27
Gene ID : 1027
mRNA Refseq : NM_004064
Protein Refseq : NP_004055
MIM : 600778
UniProt ID : P46527
Chromosome Location : 12p13.1-p12
Pathway : Cell cycle; Chronic myeloid leukemia; ErbB signaling pathway; Pathways in cancer; Prostate cancer; Small cell lung cancer
Function : cyclin-dependent protein kinase inhibitor activity; protein binding; protein kinase inhibitor activity; transforming growth factor beta receptor, cytoplasmic mediator activity

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