"RELB" Related Products

Expand

Recombinant Human RELB, His-tagged

Cat. No.: RELB-1487H
Product Overview: Recombinant full-length human Rel B was expressed by baculovirus inSf9insect cells using an N-terminal His tag. MW = 68 kDa.
Description: Rel B is part of the NFκB complex and forms heterodimeric complexes with p50 (NFKB1) and p52 (NFKB2). The homodimeric complexes of Rel B alone do not show DNA-binding activity. IHC analysis has shown that Rel B expression correlated with dendritic cell activation. NFκB-inducing kinase NIK is required for osteoclastogenesis in response to pathologic stimuli and overexpression of Rel B rescues differentiation of mouse NIK -/- osteoclast precursors. Rel B is required for RANKL-induced osteoclastogenesis in vitro and for TNF -induced bone resorption in vivo. This indicates that the alternative NFκB pathway, via Rel B, plays an essential and unique role in RANKL signaling toward osteoclast development.
Source: Sf9 insect cells using baculovirus.
Sequence: Full-length.
Applications: Western Blot.
Storage And Stability: Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name: RELB v-rel reticuloendotheliosis viral oncogene homolog B [ Homo sapiens ]
Synonyms: RELB; v-rel reticuloendotheliosis viral oncogene homolog B; IREL; I-REL; REL-B; v-rel reticuloendotheliosis viral oncogene homolog B, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3; v-rel avian reticuloendotheliosis viral oncogene homolog B (nuclear factor of kappa light polypeptide gene enhancer in B-cells 3); Transcription factor RelB; I-Rel; reticuloendotheliosis viral oncogene homolog B
Gene ID: 5971
mRNA Refseq: NM_006509
Protein Refseq: NP_006500
MIM: 604758
UniProt ID: Q01201
Chromosome Location: 19q13.32
Pathway: MAPK signaling pathway
Function: protein binding; transcription corepressor activity; transcription factor activity

Online Inquiry

Note: There will be extra charge for optional service!
Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information


Price does not include shipping and packaging costs.Request quote for final price.

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.