Recombinant Human RELB, His-tagged
| Cat.No. : |
RELB-1487H |
| Product Overview : |
Recombinant full-length human Rel B was expressed by baculovirus inSf9insect cells using an N-terminal His tag. MW = 68 kDa. |
- Specification
- Gene Information
- Related Products
| Cat. No. : |
RELB-1487H |
| Description : |
Rel B is part of the NFκB complex and forms heterodimeric complexes with p50 (NFKB1) and p52 (NFKB2). The homodimeric complexes of Rel B alone do not show DNA-binding activity. IHC analysis has shown that Rel B expression correlated with dendritic cell activation. NFκB-inducing kinase NIK is required for osteoclastogenesis in response to pathologic stimuli and overexpression of Rel B rescues differentiation of mouse NIK -/- osteoclast precursors. Rel B is required for RANKL-induced osteoclastogenesis in vitro and for TNF -induced bone resorption in vivo. This indicates that the alternative NFκB pathway, via Rel B, plays an essential and unique role in RANKL signaling toward osteoclast development. |
| Source : |
Sf9 insect cells using baculovirus. |
| Sequence : |
Full-length. |
| Applications : |
Western Blot. |
| Storage And Stability : |
Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
| Gene Name : |
RELB v-rel reticuloendotheliosis viral oncogene homolog B [ Homo sapiens ] |
| Synonyms : |
RELB; v-rel reticuloendotheliosis viral oncogene homolog B; IREL; I-REL; REL-B; v-rel reticuloendotheliosis viral oncogene homolog B, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3; v-rel avian reticuloendotheliosis viral oncogene homolog B (nuclear factor of kappa light polypeptide gene enhancer in B-cells 3); Transcription factor RelB; I-Rel; reticuloendotheliosis viral oncogene homolog B |
| Gene ID : |
5971 |
| mRNA Refseq : |
NM_006509 |
| Protein Refseq : |
NP_006500 |
| MIM : |
604758 |
| UniProt ID : |
Q01201 |
| Chromosome Location : |
19q13.32 |
| Pathway : |
MAPK signaling pathway |
| Function : |
protein binding; transcription corepressor activity; transcription factor activity |
Products Types
Related Gene
RELB
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
