"RELB" Related Products


Recombinant Human RELB, His-tagged

Cat. No.: RELB-1487H
Product Overview: Recombinant full-length human Rel B was expressed by baculovirus inSf9insect cells using an N-terminal His tag. MW = 68 kDa.
Description: Rel B is part of the NFκB complex and forms heterodimeric complexes with p50 (NFKB1) and p52 (NFKB2). The homodimeric complexes of Rel B alone do not show DNA-binding activity. IHC analysis has shown that Rel B expression correlated with dendritic cell activation. NFκB-inducing kinase NIK is required for osteoclastogenesis in response to pathologic stimuli and overexpression of Rel B rescues differentiation of mouse NIK -/- osteoclast precursors. Rel B is required for RANKL-induced osteoclastogenesis in vitro and for TNF -induced bone resorption in vivo. This indicates that the alternative NFκB pathway, via Rel B, plays an essential and unique role in RANKL signaling toward osteoclast development.
Source: Sf9 insect cells using baculovirus.
Sequence: Full-length.
Applications: Western Blot.
Storage And Stability: Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name: RELB v-rel reticuloendotheliosis viral oncogene homolog B [ Homo sapiens ]
Synonyms: RELB; v-rel reticuloendotheliosis viral oncogene homolog B; IREL; I-REL; REL-B; v-rel reticuloendotheliosis viral oncogene homolog B, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3; v-rel avian reticuloendotheliosis viral oncogene homolog B (nuclear factor of kappa light polypeptide gene enhancer in B-cells 3); Transcription factor RelB; I-Rel; reticuloendotheliosis viral oncogene homolog B
Gene ID: 5971
mRNA Refseq: NM_006509
Protein Refseq: NP_006500
MIM: 604758
UniProt ID: Q01201
Chromosome Location: 19q13.32
Pathway: MAPK signaling pathway
Function: protein binding; transcription corepressor activity; transcription factor activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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