Recombinant Human CD40LG, His-tagged
Cat.No. : | CD40LG-27811TH |
Product Overview : | Recombinant full length soluble Human CD40LG with an N terminal His tag; 169 amino acids including tag, predicted MWt: 18.3kDa. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome. |
Protein length : | 149 amino acids |
Conjugation : | HIS |
Molecular Weight : | 18.300kDa inclusive of tags |
Source : | E. coli |
Tissue specificity : | Specifically expressed on activated CD4+ T-lymphocytes. |
Form : | Liquid |
Purity : | >95% by SDS-PAGE |
Storage buffer : | Preservative: NoneConstituents: 40% Glycerol, 0.2M Sodium chloride, 20mM Tris HCl, 1mM DTT, pH 8.0 |
Storage : | Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. |
Sequences of amino acids : | MGSSHHHHHHSSGLVPRGSHMQKGD QNPQIAAHVISEASSKTTSVLQWAE KGYYTMSNNLVTLENGKQLTVKRQG LYYIYAQVTFCSNREASSQAPFIAS LCLKSPGRFERILLRAANTHSSAKP CGQQSIHLGGVFELQPGASVFVNVT DPSQVSHGTGFTSFGLLKL |
Sequence Similarities : | Belongs to the tumor necrosis factor family. |
Gene Name : | CD40LG CD40 ligand [ Homo sapiens ] |
Official Symbol : | CD40LG |
Synonyms : | CD40LG; CD40 ligand; HIGM1, IMD3, TNFSF5, tumor necrosis factor (ligand) superfamily, member 5 (hyper IgM syndrome); CD40 antigen ligand; CD40L; CD154; gp39; hCD40L; hyper IgM syndrome; T B cell activating molecule; TNF related activation protein; TRAP; |
Gene ID : | 959 |
mRNA Refseq : | NM_000074 |
Protein Refseq : | NP_000065 |
MIM : | 300386 |
Uniprot ID : | P29965 |
Chromosome Location : | Xq26 |
Pathway : | Adaptive Immune System, organism-specific biosystem; Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Asthma, organism-specific biosystem; Asthma, conserved biosystem; |
Function : | CD40 receptor binding; cytokine activity; tumor necrosis factor receptor binding; |
Products Types
◆ Recombinant Protein | ||
Cd40lg-4371M | Recombinant Mouse Cd40lg Protein | +Inquiry |
CD40LG-12H | Active Recombinant Human CD40LG Protein (116-261), N-FLAG tagged, Certified Serum Grade | +Inquiry |
CD40LG-911R | Recombinant Rat CD40LG Protein, His (Fc)-Avi-tagged | +Inquiry |
cd40lg-681Z | Recombinant Zebrafish cd40lg Protein, His-tagged | +Inquiry |
CD40LG-634H | Recombinant Human CD40LG Protein | +Inquiry |
◆ Lysates | ||
CD40LG-1965HCL | Recombinant Human CD40LG cell lysate | +Inquiry |
CD40LG-1205RCL | Recombinant Rat CD40LG cell lysate | +Inquiry |
CD40LG-001CCL | Recombinant Canine CD40LG cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, there are clinical trials investigating the modulation of CD40LG in autoimmune diseases, exploring its potential role in regulating immune responses that contribute to autoimmunity.
Yes, research suggests that CD40LG modulation might be a viable strategy in the development of treatments for infectious diseases by enhancing immune responses.
The interaction between CD40LG and CD40 is crucial for the activation of B cells, leading to the production of antibodies and the development of an effective immune response.
CD40LG is involved in modulating inflammatory responses by influencing the activation and function of immune cells, contributing to the regulation of the immune system.
CD40LG is being investigated as an adjuvant in vaccine development, aiming to enhance the immune response and improve the efficacy of vaccines against various diseases.
Customer Reviews (3)
Write a reviewThe reliable performance of the CD40LG protein in ELISA and its compatibility with protein electron microscopy structure analysis make it an excellent choice for a wide range of research studies.
Its reliable and accurate performance ensures dependable results, contributing to the advancement of scientific knowledge in various fields of study.
Their knowledgeable and responsive team assists in troubleshooting and finding solutions to any experimental challenges that may arise.
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