||Recombinant full length Human CDC42 with N terminal proprietary tag; amino acids 1-188, 48kDa.
||The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants.
||Lyophilised:Reconstitute in 20mM HEPES, pH 7.0, Packaging size : 0.2 mg
||>95% by SDS-PAGE
||Preservative: NoneConstituents: 50mM Sodium chloride, 20mM HEPES, 1mM EDTA, pH 7.5
||Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
||Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.