Recombinant Human CDC42

• Cat.No.: CDC42-26610TH
• Product Overview: Recombinant full length Human CDC42 with N terminal proprietary tag; amino acids 1-188, 48kDa.

Specification

• Description: The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants.
• Source: E. coli
• Form: Lyophilised:Reconstitute in 20mM HEPES, pH 7.0, Packaging size : 0.2 mg
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 50mM Sodium chloride, 20mM HEPES, 1mM EDTA, pH 7.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequence Similarities: Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.

Gene Information

• Gene Name: CDC42 cell division cycle 42 (GTP binding protein, 25kDa) [ Homo sapiens ]
• Official Symbol: CDC42
• Synonyms: CDC42; cell division cycle 42 (GTP binding protein, 25kDa); cell division cycle 42 (GTP binding protein, 25kD); cell division control protein 42 homolog; CDC42Hs; G25K
• Gene ID: 998
• mRNA Refseq: NM_001039802
• Protein Refseq: NP_001034891
• MIM: 116952
• Uniprot ID: P60953
• Chromosome Location: 1p36.1
• Function: GTP binding; GTP-dependent protein binding; GTPase activity; GTPase activity; mitogen-activated protein kinase kinase kinase binding