"CENPA" Related Products

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Recombinant Human CENPA, His-tagged

Cat.No.: CENPA-27391TH
Product Overview: Recombinant Full Length Human CENPA produced in Sf9 Insect cells with a 6x His tag, 17,015 Dalton.
Description: Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Conjugation: HIS
Biological activity: CENPA-27391TH reacts with Scleroderma patient sera.
Form: Liquid
Purity: >90% by SDS-PAGE
Storage buffer: Preservative: NoneConstituents: 6M Urea, 20mM HEPES, 100mM Sodium chloride, pH 8
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
Sequence Similarities: Belongs to the histone H3 family.
Gene Name: CENPA centromere protein A [ Homo sapiens ]
Official Symbol: CENPA
Synonyms: CENPA; centromere protein A; centromere protein A (17kD) , centromere protein A, 17kDa; histone H3-like centromeric protein A; CENP A;
Gene ID: 1058
mRNA Refseq: NM_001042426
Protein Refseq: NP_001035891
MIM: 117139
Uniprot ID: P49450
Chromosome Location: 2p24-p21
Pathway: Aurora A signaling, organism-specific biosystem; Aurora B signaling, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; Chromosome Maintenance, organism-specific biosystem; DNA Replication, organism-specific biosystem;
Function: DNA binding; chromatin binding; protein binding;

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