Recombinant Human CENPA, His-tagged CENPA-27391TH

Recombinant Human CENPA, His-tagged

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Recombinant Human CENPA, His-tagged

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Cat.No. : CENPA-27391TH
Product Overview : Recombinant Full Length Human CENPA produced in Sf9 Insect cells with a 6x His tag, 17,015 Dalton.
Description : Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Conjugation : HIS
Biological activity : CENPA-27391TH reacts with Scleroderma patient sera.
Form : Liquid
Purity : >90% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 6M Urea, 20mM HEPES, 100mM Sodium chloride, pH 8
Storage : Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
Sequence Similarities : Belongs to the histone H3 family.
Gene Name : CENPA centromere protein A [ Homo sapiens ]
Official Symbol : CENPA
Synonyms : CENPA; centromere protein A; centromere protein A (17kD) , centromere protein A, 17kDa; histone H3-like centromeric protein A; CENP A;
Gene ID : 1058
mRNA Refseq : NM_001042426
Protein Refseq : NP_001035891
MIM : 117139
Uniprot ID : P49450
Chromosome Location : 2p24-p21
Pathway : Aurora A signaling, organism-specific biosystem; Aurora B signaling, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; Chromosome Maintenance, organism-specific biosystem; DNA Replication, organism-specific biosystem;
Function : DNA binding; chromatin binding; protein binding;

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