Recombinant Human CENPA, His-tagged

• Cat.No.: CENPA-27391TH
• Product Overview: Recombinant Full Length Human CENPA produced in Sf9 Insect cells with a 6x His tag, 17,015 Dalton.

Specification

• Description: Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
• Conjugation: HIS
• Biological activity: CENPA-27391TH reacts with Scleroderma patient sera.
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 6M Urea, 20mM HEPES, 100mM Sodium chloride, pH 8
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
• Sequence Similarities: Belongs to the histone H3 family.

Gene Information

• Gene Name: CENPA centromere protein A [ Homo sapiens ]
• Official Symbol: CENPA
• Synonyms: CENPA; centromere protein A; centromere protein A (17kD) , centromere protein A, 17kDa; histone H3-like centromeric protein A; CENP A
• Gene ID: 1058
• mRNA Refseq: NM_001042426
• Protein Refseq: NP_001035891
• MIM: 117139
• Uniprot ID: P49450
• Chromosome Location: 2p24-p21
• Pathway: Aurora A signaling, organism-specific biosystem; Aurora B signaling, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; Chromosome Maintenance, organism-specific biosystem; DNA Replication, organism-specific biosystem
• Function: DNA binding; chromatin binding; protein binding