Recombinant Human CFL2, His-tagged CFL2-26843TH

Recombinant Human CFL2, His-tagged

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Recombinant Human CFL2, His-tagged

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Cat.No. : CFL2-26843TH
Product Overview : Recombinant full length Human Cofilin 2 with an N terminal His tag; 186aa, 20.9kDa inclusive of tag.
Description : This gene encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. This protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH-dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants.
Protein length : 166 amino acids
Conjugation : HIS
Molecular Weight : 20.900kDa inclusive of tags
Source : E. coli
Tissue specificity : Isoform CFL2b is expressed predominantly in skeletal muscle and heart. Isoform CFL2a is expressed in various tissues.
Form : Liquid
Purity : >90% by SDS-PAGE
Storage buffer : pH: 8.00Constituents:0.32% Tris HCl, 10% Glycerol, 0.04% DTT, 0.29% Sodium chloride
Storage : Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids : MGSSHHHHHHSSGLV PRGSHMASGVTVNDE VIKVFNDMKVRKSST QEEIKKRKKAVLFCL SDDKRQIIVEEAKQI LVGDIGDTVEDPYTS FVKLLPLNDCRYALY DATYETKESKKEDLV FIFWAPESAPLKSKM IYASSKDAIKKKFTG IKHEWQVNGLDDIKD RSTLGEKLGGNVVVS LEGKPL
Sequence Similarities : Belongs to the actin-binding proteins ADF family.Contains 1 ADF-H domain.
Gene Name : CFL2 cofilin 2 (muscle) [ Homo sapiens ]
Official Symbol : CFL2
Synonyms : CFL2; cofilin 2 (muscle); cofilin-2;
Gene ID : 1073
mRNA Refseq : NM_001243645
Protein Refseq : NP_001230574
MIM : 601443
Uniprot ID : Q9Y281
Chromosome Location : 14q13.2
Pathway : Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; Caspase cascade in apoptosis, organism-specific biosystem; Fc gamma R-mediated phagocytosis, organism-specific biosystem; Fc gamma R-mediated phagocytosis, conserved biosystem;
Function : actin binding; protein binding;

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