Recombinant Human CHMP2A, His-tagged
Cat.No. : | CHMP2A-26719TH |
Product Overview : | Recombinant full length Human CHMP2A, His-tagged at N terminal and expressed in E.coli. |
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Description : | CHMP2A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al. |
Conjugation : | HIS |
Source : | E. coli |
Form : | Liquid |
Purity : | >90% by SDS-PAGE |
Storage buffer : | Preservative: NoneConstituents: 30% Glycerol, 0.1M Sodium chloride, 20mM Tris HCl, 1mM DTT, pH 8.0 |
Storage : | Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. |
Gene Name : | CHMP2A charged multivesicular body protein 2A [ Homo sapiens ] |
Official Symbol : | CHMP2A |
Synonyms : | CHMP2A; charged multivesicular body protein 2A; chromatin modifying protein 2A; charged multivesicular body protein 2a; BC 2; CHMP2; putative breast adenocarcinoma marker (32kD); VPS2; VPS2 homolog A (S. cerevisiae); VPS2A; |
Gene ID : | 27243 |
mRNA Refseq : | NM_014453 |
Protein Refseq : | NP_055268 |
MIM : | 610893 |
Uniprot ID : | O43633 |
Chromosome Location : | 19q13.43 |
Pathway : | ESCRT-III complex, organism-specific biosystem; Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem; Endosomal Sorting Complex Required For Transport (ESCRT), organism-specific biosystem; Membrane Trafficking, organism-specific biosystem; |
Function : | protein domain specific binding; |
Products Types
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◆ Lysates | ||
CHMP2A-7532HCL | Recombinant Human CHMP2A 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionResearch into potential therapies targeting CHMP2A is ongoing, but no specific treatments have been approved yet.
CHMP2A is involved in the autophagic process by helping in the formation of autophagosomes and lysosome fusion, which is essential for cellular recycling.
Dysfunction in CHMP2A can disrupt cellular homeostasis by impairing the proper sorting and degradation of cellular components, leading to cellular stress.
CHMP2A mutations can be detected in some cases of hereditary spastic paraplegia, but it's not commonly used as a diagnostic marker for other neurodegenerative diseases.
CHMP2A plays a role in antigen presentation, and its dysfunction could impact the immune response.
Customer Reviews (3)
Write a reviewSuch manufacturer support fosters a conducive environment for successful and impactful research outcomes.
By considering these advantages and the supportive role of manufacturers, researchers studying CHMP2A protein can benefit from high-quality products, technical assistance, customization options, product validation, and potential collaborations.
This information ensures that researchers have a clear understanding of the product's performance attributes, and enables them to select the most suitable protein preparation for their experiments.
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