"Atg7" Related Products


Recombinant Mouse Autophagy-Related 7 (Yeast), His-tagged

Cat. No.: Atg7-1524M
Product Overview: Recombinant mouse Atg7 (aa. 50-698) produced inE.coliis a 30 kDa protein. It was fused to C-terminal His-tag.
Description: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. Another member of the autophagy family of proteins is APG7 which was identified in yeast as a ubiquitin-E1-like enzyme; this function is conserved in the mammalian homolog. In mammalian cells, APG7 is essential for autophagy conjugation systems, autophagosome formation, starvation-induced bulk degradation of proteins and organelles. It has been suggested that caspase-8 may alter APG7 levels and thus the APG7 program of autophagic cell death.
Source: E.coli.
Purity: 95%.
Application: This recombinant protein can be used for WB, ELISA, MS and neutralization assays.
Tested Application: E, WB, MS.
Buffer: 1X PBS containing 10% glycerol.
Species Reactivity: n/a.
Storage: Store at -70°C with any protein, exposing ATG7 recombinant protein to repeated freeze/thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
Pathways: Regulation of autophagy
Gene Name: Atg7 autophagy-related 7 (yeast) [ Mus musculus ]
Synonyms: autophagy-related 7 (yeast); Agp7; Apg7l; Atg7l; 1810013K23Rik; Atg7; AGP7; autophagy 7-like; autophagy-related 7-like
Gene ID: 74244
mRNA Refseq: NM_028835
Protein Refseq: NP_083111
UniProt ID: Q9D906
Chromosome Location: 6 E3
Function: catalytic activity; protein binding; ubiquitin activating enzyme activity

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