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Recombinant Human CLCF1 protein

Cat.No. : CLCF1-30449TH
Product Overview : Recombinant Human CLCF1 protein was expressed in Escherichia coli.
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  • Gene Information
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Description : Novel Neurotrophin-1 (NNT-1) or B-Cell Stimulating Factor-3 (BSF-3), is a new member of the IL-6 family of structurally related cytokines that includes IL-6, CNTF, LIF, CT-1, IL-11 and OSM. All family members share the receptor subunit gp130 that belong to the type I cytokine receptor superfamily. Ligand binding leads to gp130 homodimerization or heterodimerization (with LIF receptor or OSM receptor beta), and induces cell signaling and functional activity. For several family members, including CNTF, IL-6, and IL-11, binding of the ligand to a specific receptor alpha subunit (CNTF R alpha, IL-6 R alpha, or IL-11 R alpha) is required prior to gp130 homo- or hetero-dimerization.
Source : E.coli
Species : Human
Form : Lyophilized from a 0.2μm filtered concentrated solution in 30 % Acetonitrile and 0.1 % TFA.
Bio-activity : Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human TF-1 cells is less than 4 ng/ml, corresponding to a specific activity of > 2.5 × 10⁵ IU/mg in the presence of human CNTF R alpha.
Molecular Mass : Approximately 22.3 kDa, a single non-glycosylated polypeptide chain containing 198 amino acids.
Protein length : 198
AA Sequence : LNRTGDPGPGPSIQKTYDLTRYLEH QLRSLAGTYLNYLGPPFNEPDFNPP RLGAETLPRATVDLEVWRSLNDKLR LTQNYEAYSHLLCYLRGLNRQAATA ELRRSLAHFCTSLQGLLGSIAGVMA ALGYPLPQPLPGTEPTWTPGPAHSD FLQKMDDFWLLKELQTWLWRSAKDF NRLKKKMQPPAAAVTLHLGAHGF
Endotoxin : Less than 0.1 EU/μg of rHuNNT-1/BCSF-3 as determined by LAL method.
Purity : >98% by SDS-PAGE and HPLC analysis.
Storage : Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
Reconstitution : We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤-20 centigrade. Further dilutions should be made in appropriate buffered solutions.
Gene Name : CLCF1
Official Symbol : CLCF1
Synonyms : CLCF1; cardiotrophin-like cytokine factor 1; CRLF1 associated cytokine like factor 1; B cell stimulating factor 3; BSF 3; BSF3; CISS2; CLC; cold induced sweating syndrome 2; NNT 1; NNT1; novel neurotrophin 1; NR6; novel neurotrophin-1; B-cell stimulating factor 3; B-cell stimulatory factor 3; B-cell-stimulating factor 3; CRLF1 associated cytokine-like factor 1; neurotrophin-1/B-cell stimulating factor-3; BSF-3; NNT-1;
Gene ID : 23529
mRNA Refseq : NM_001166212
Protein Refseq : NP_001159684
MIM : 607672
UniProt ID : Q9UBD9

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can CLCF1 be measured as a biomarker for certain diseases? 07/22/2021

Research suggests that levels of CLCF1 in blood or tissues may serve as potential biomarkers for specific diseases, aiding in early diagnosis and prognosis.

How is CLCF1 production regulated in the human body? 09/05/2020

The production of CLCF1 is tightly regulated at the transcriptional and post-translational levels, involving various signaling pathways.

Are there any clinical trials exploring the use of CLCF1 in medical interventions? 12/04/2018

Yes, there are ongoing clinical trials investigating the therapeutic potential of CLCF1 in various diseases, including autoimmune disorders and neurodegenerative conditions.

How does CLCF1 interact with other cytokines in the IL-6 family? 08/17/2018

CLCF1 can interact with various receptors and signaling molecules within the IL-6 cytokine family, influencing a range of physiological processes.

In what ways does CLCF1 contribute to neurodegenerative disorders? 10/19/2017

Studies have indicated that CLCF1 may play a role in neurodegenerative conditions, and understanding its function could lead to potential therapies for diseases like Alzheimer's and Parkinson's.

Customer Reviews (3)

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Reviews
10/25/2019

    With their meticulous documentation and support, I am confident that my utilization of CLCF1 protein in clinical trials will meet all necessary regulations and guidelines.

    05/07/2017

      the manufacturer's supply management capabilities assure a seamless and continuous provision of the CLCF1 protein.

      09/19/2016

        In addition to the remarkable quality of the protein, the manufacturer's support extends beyond the provision of the product itself.

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