Recombinant Human COL18A1

• Cat.No.: COL18A1-28560TH
• Product Overview: Human Recombinant Full Length Endostatin produced in Pichia Pastoris.A single, glycosylated, polypeptide having a total molecular weight of20 kDa.

Specification

• Description: This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. The proteolytically produced C-terminal fragment of type XVIII collagen is endostatin, a potent antiangiogenic protein. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Tissue specificity: Present in multiple organs with highest levels in liver, lung and kidney.
• Biological activity: The activity calculated by ECE migration inhibition was found to be 50,000IU/mg.
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: PBS
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: Amino Acid Composition is in total agreement with the expected amino acid composition of native human Endostatin.
• Sequence Similarities: Belongs to the multiplexin collagen family.Contains 1 FZ (frizzled) domain.Contains 1 TSP N-terminal (TSPN) domain.

Gene Information

• Gene Name: COL18A1 collagen, type XVIII, alpha 1 [ Homo sapiens ]
• Official Symbol: COL18A1
• Synonyms: COL18A1; collagen, type XVIII, alpha 1; KNO, Knobloch syndrome, type 1; collagen alpha-1(XVIII) chain; endostatin; KNO1; KS
• Gene ID: 80781
• mRNA Refseq: NM_030582
• Protein Refseq: NP_085059
• MIM: 120328
• Uniprot ID: P39060
• Chromosome Location: 21q22.3
• Pathway: Direct p53 effectors, organism-specific biosystem; FOXA1 transcription factor network, organism-specific biosystem; Protein digestion and absorption, organism-specific biosystem; Protein digestion and absorption, conserved biosystem
• Function: metal ion binding; protein binding; structural molecule activity