Recombinant Human EIF3I, T7-tagged
Cat.No. : | EIF3I-1534H |
Product Overview : | Recombinant Human EIF3I was expressed inE.Coliusing an N-terminal T7 tag. MW=37.4 kDa. |
- Specification
- Gene Information
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Cat. No. : | EIF3I-1534H |
Description : | Eukaryotic initiation factor 3 (eIF3) is the largest of the eIFs and consists of at least 10 nonidentical subunits in mammals. In S. cerevisiae, the p39 subunit of eIF3 contains WD repeats, which are thought to mediate protein-protein interactions. The p39 protein appears to be essential for maintaining the integrity of the yeast eIF3 complex. The mammalian eIF3-p36 subunit is homologous to yeast p39. |
Source : | E.Coli. |
Sequence : | 1-325. |
Purity : | ~95%. |
Specific Activity : | n/aH. |
Preparation : | 0.1mg/0.46 ml. |
Applications : | E, WB, MS. |
Buffer : | 10 mM Tris, pH 8.0, 0.1% Triton X-100, 0.002% NaN3. |
Storage : | Store at -70?C. As with any protein, exposing EIF3I recombinant protein to repeated freeze/thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature. |
SDS-PAGE : | SDS PAGE Analysis of EIF3I Recombinant Protein. 4-20% SDS gradient gel. Coomassie blue staining. |
Gene Name : | EIF3I eukaryotic translation initiation factor 3, subunit I [ Homo sapiens ] |
Synonyms : | EIF3I; eukaryotic translation initiation factor 3, subunit I; TGF-beta receptor-interacting protein 1; TGFbeta receptor-interacting protein 1; eukaryotic translation initiation factor 3, subunit 2 (beta, 36kD); eukaryotic translation initiation factor 3, subunit 2 beta, 36kDa; predicted protein of HQ2242; TRIP1; EIF3S2; TRIP-1; PRO2242; eIF3-p36; eIF3-beta |
Gene ID : | 8668 |
mRNA Refseq : | NM_003757 |
Protein Refseq : | NP_003748 |
MIM : | 603911 |
UniProt ID : | Q13347 |
Chromosome Location : | 1p34.1 |
Pathway : | Gene Expression; Metabolism of proteins |
Function : | protein binding; translation initiation factor activity |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionThe protein is part of the EIF3 complex, which is involved in mRNA recognition and ligation by interacting with other EIF3 subunits, facilitating the post-transcriptional protein translation process.
EIF3I protein may be associated with cell cycle regulation. Some studies have shown that the expression level of EIF3I protein may vary at different stages of the cell cycle, but the specific regulatory mechanism needs further study.
Yes, the EIF3I protein can interact with other EIF3 subunits to form the EIF3 complex. The interaction between these subunits is to synergistically regulate the progress of protein synthesis.
Yes, there are differences in the expression levels of EIF3I protein in different tissues. For example, in some tumor tissues, the expression level of the EIF3I protein is significantly elevated.
EIF3I protein is associated with the occurrence and progression of a variety of diseases. For example, in some tumor cells, elevated levels of EIF3I protein are associated with enhanced proliferation, invasion, and metastasis of tumor cells. In addition, the EIF3I protein has been linked to some neurological diseases, such as Parkinson's disease.
There are currently no specific drugs designed to regulate the expression or function of the EIF3I protein. However, drug discovery targeting the EIF3 complex may affect the function of the EIF3I protein.
Customer Reviews (3)
Write a reviewStability of EIF3I is very good, and it can maintain a stable performance even after multiple uses, which gives me more confidence in the experimental results.
The band positions of EIF3I in Western blot were accurate and showed good specificity.
Their service attitude is very good, always patiently answer our questions.
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