Recombinant Human EIF3I protein, T7-tagged
Cat.No. : | EIF3I-223H |
Product Overview : | Recombinant human EIF3I (325aa) fused with T7 Tag at N-terminal was expressed in E. coli. |
- Specification
- Gene Information
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Source : | E. coli |
Species : | Human |
Tag : | T7 |
Form : | 1.0 mg/ml, sterile-filtered, in 20 mM pH 8.0 Tris-HCl Buffer, with proprietary formulation of NaCl, KCl, EDTA, Sucrose and DTT. |
AA Sequence : | MASMTGGQQMGRGEFMKPILLQGHE RSITQIKYNREGDLLFTVAKDPIVN VWYSVNGERLGTYMGHTGAVWCVDA DWDTKHVLTGSADNSCRLWDCETGK QLALLKTNSAVRTCGFDFGGNIIMF STDKQMGYQCFVSFFDLRDPSQIDN NEPYMKIPCNDSKITSAVWGPLGEC IIAGHESGELNQYSAKSGEVLVNVK EHSRQINDIQLSRDMTMFVTASKDN TAKLFDSTTLEHQKTFRTERPVNSA ALSPNYDHVVLGGGQEAMDVTTTST RIGKFEARFFHLAFEEEFGRVKGHF GPINSVAFHPDGKSYSSGGEDGYVR IHYFDPQYFEFEFEA |
Purity : | >90% by SDS-PAGE. |
Applications : | 1. May be used for in vitro TGFb1 mediated EMT regulation study with intracellular delivery of this protein.2. As soluble / native protein, may be used as enzymatic substrate protein for kinase and ubiquitin assay development.3. May be used for mapping EIF3I protein-protein interaction.4. May be used as antigen for specific antibody development. |
Storage : | Keep at -80°C for long term storage. Product is stable at 4 °C for at least 7 days. |
Gene Name : | EIF3I eukaryotic translation initiation factor 3, subunit I [ Homo sapiens ] |
Official Symbol : | EIF3I |
Synonyms : | EIF3I; eIF3 beta; eIF3 p36; eIF3i; TRIP 1; eIF-3-beta; predicted protein of HQ2242; TGFbeta receptor-interacting protein 1; TGF-beta receptor-interacting protein 1; TRIP1; EIF3S2; TRIP-1; PRO2242; eIF3-p36; eIF3-beta; |
Gene ID : | 8668 |
mRNA Refseq : | NM_003757 |
Protein Refseq : | NP_003748 |
MIM : | 603911 |
UniProt ID : | Q13347 |
Chromosome Location : | 1p34.1 |
Pathway : | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, organism-specific biosystem; Cap-dependent Translation Initiation, organism-specific biosystem; Eukaryotic Translation Initiation, organism-specific biosystem; Formation of a pool of free 40S subunits, organism-specific biosystem; Formation of the ternary complex, and subsequently, the 43S complex, organism-specific biosystem; GTP hydrolysis and joining of the 60S ribosomal subunit, organism-specific biosystem; Gene Expression, organism-specific biosystem; |
Function : | protein binding; contributes_to translation initiation factor activity; translation initiation factor activity; translation initiation factor activity; |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionThe protein is part of the EIF3 complex, which is involved in mRNA recognition and ligation by interacting with other EIF3 subunits, facilitating the post-transcriptional protein translation process.
EIF3I protein may be associated with cell cycle regulation. Some studies have shown that the expression level of EIF3I protein may vary at different stages of the cell cycle, but the specific regulatory mechanism needs further study.
Yes, the EIF3I protein can interact with other EIF3 subunits to form the EIF3 complex. The interaction between these subunits is to synergistically regulate the progress of protein synthesis.
Yes, there are differences in the expression levels of EIF3I protein in different tissues. For example, in some tumor tissues, the expression level of the EIF3I protein is significantly elevated.
EIF3I protein is associated with the occurrence and progression of a variety of diseases. For example, in some tumor cells, elevated levels of EIF3I protein are associated with enhanced proliferation, invasion, and metastasis of tumor cells. In addition, the EIF3I protein has been linked to some neurological diseases, such as Parkinson's disease.
There are currently no specific drugs designed to regulate the expression or function of the EIF3I protein. However, drug discovery targeting the EIF3 complex may affect the function of the EIF3I protein.
Customer Reviews (3)
Write a reviewStability of EIF3I is very good, and it can maintain a stable performance even after multiple uses, which gives me more confidence in the experimental results.
The band positions of EIF3I in Western blot were accurate and showed good specificity.
Their service attitude is very good, always patiently answer our questions.
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