Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human CRKL, His-tagged

Cat.No. : CRKL-26624TH
Product Overview : Recombinant full length Human CrkL with an N terminal His tag; 323 amino acids with tag, predicted MWt 35.9 kDa.
  • Specification
  • Gene Information
  • Related Products
Description : This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.
Protein length : 303 amino acids
Conjugation : HIS
Molecular Weight : 35.900kDa inclusive of tags
Source : E. coli
Form : Liquid
Purity : >90% by SDS-PAGE
Storage buffer : pH: 8.00Constituents:0.32% Tris HCl, 10% Glycerol, 0.03% DTT, 0.58% Sodium chloride
Storage : Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids : MGSSHHHHHHSSGLVPRGSHMSSARFDSSDRSAWYMGPVS RQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSH YIINSLPNRRFKIGDQEFDHLPALLEFYKIHYLDTTTLIE PAPRYPSPPMGSVSAPNLPTAEDNLEYVRTLYDFPGNDAE DLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVEK LVRSSPHGKHGNRNSNSYGIPEPAHAYAQPQTTTPLPAVS GSPGAAITPLPSTQNGPVFAKAIQKRVPCAYDKTALALEV GDIVKVTRMNINGQWEGEVNGRKGLFPFTHVKIFDPQNPD ENE
Sequence Similarities : Belongs to the CRK family.Contains 1 SH2 domain.Contains 2 SH3 domains.
Gene Name : CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like [ Homo sapiens ]
Official Symbol : CRKL
Synonyms : CRKL; v-crk sarcoma virus CT10 oncogene homolog (avian)-like; v crk avian sarcoma virus CT10 oncogene homolog like; crk-like protein;
Gene ID : 1399
mRNA Refseq : NM_005207
Protein Refseq : NP_005198
MIM : 602007
Uniprot ID : P46109
Chromosome Location : 22q11.21
Pathway : B Cell Receptor Signaling Pathway, organism-specific biosystem; Bacterial invasion of epithelial cells, organism-specific biosystem; Bacterial invasion of epithelial cells, conserved biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem;
Function : SH3/SH2 adaptor activity; protein binding; protein tyrosine kinase activity; signal transducer activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All CRKL Products

Required fields are marked with *

My Review for All CRKL Products

Required fields are marked with *

0

Inquiry Basket

cartIcon
logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends