Native Human CSH1

• Cat.No.: CSH1-31024TH
• Product Overview: Full length native Human Placental lactogen purified from Human placental tissue, predicted MWt 22kDa.

Specification

• Description: The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, although the ratio of 1 to 2 increases by term. Mutations in this gene result in placental lactogen deficiency and Silver-Russell syndrome.
• Protein length: 191 amino acids
• Molecular Weight: 22.000kDa
• Form: Lyophilised:Reconstitution with phosphate buffer, pH >7.0 containing 0.15M NaCl is recommended.
• Purity: by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 0.02M Ammonium bicarbonate
• Storage: Store at +4°C.

Gene Information

• Gene Name: CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) [ Homo sapiens ]
• Official Symbol: CSH1
• Synonyms: CSH1; chorionic somatomammotropin hormone 1 (placental lactogen); chorionic somatomammotropin hormone; choriomammotropin; chorionic somatomammotropin A; CSA; CSMT; FLJ75407; hCS A; PL; placental lactogen
• Gene ID: 1442
• mRNA Refseq: NM_001317
• Protein Refseq: NP_001308
• MIM: 150200
• Uniprot ID: P01243
• Chromosome Location: 17q22-q24
• Pathway: Cytokine Signaling in Immune system, organism-specific biosystem; Growth hormone receptor signaling, organism-specific biosystem; Immune System, organism-specific biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem
• Function: hormone activity; metal ion binding