"CST3" Related Products

Native Human CST3

Cat.No.: CST3-26152TH
Product Overview: Full length native protein isolated from urine (purified) (Human).
Description: The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes the most abundant extracellular inhibitor of cysteine proteases, which is found in high concentrations in biological fluids and is expressed in virtually all organs of the body. A mutation in this gene has been associated with amyloid angiopathy. Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions, establishing its role in vascular disease.
Tissue specificity: Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Expressed in various body fluids, such as the cerebrospinal fluid and plasma. Expressed in highest levels in the epididymis, vas deferens, brain, thymus, and ov
Form: Lyophilised:Use 100ul of a phosphate buffer, pH>7 containing 0.15 M NaCl to reconstitute to 1mg/ml.Single homogenous batch, lyophilised from 0.02 M NH4HCO3 may contain traces of buffer salts.
Purity: >95% by SDS-PAGE
Storage: Store at +4°C.
Sequence Similarities: Belongs to the cystatin family.
Gene Name: CST3 cystatin C [ Homo sapiens ]
Official Symbol: CST3
Synonyms: CST3; cystatin C; cystatin C (amyloid angiopathy and cerebral hemorrhage); cystatin-C;
Gene ID: 1471
mRNA Refseq: NM_000099
Protein Refseq: NP_000090
MIM: 604312
Uniprot ID: P01034
Chromosome Location: 20p11.2
Pathway: Amyloids, organism-specific biosystem; Salivary secretion, organism-specific biosystem; Salivary secretion, conserved biosystem;
Function: beta-amyloid binding; cysteine-type endopeptidase inhibitor activity; peptidase inhibitor activity; protease binding;

Online Inquiry

Note: There will be extra charge for optional service!

Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information

Optional requirements on this protein    +Expand

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.