Recombinant Human CTLA4, Fc-tagged CTLA4-28029TH

Recombinant Human CTLA4, Fc-tagged

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Recombinant Human CTLA4, Fc-tagged

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Cat.No. : CTLA4-28029TH
Product Overview : Human fusion protein homodimeric glycosylated CTLA4 produced in Sf9 insect cells. Each subunit is fused to a polypeptide linker to the Fc portion of Human IgG1.
Description : This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
Conjugation : Fc
Tissue specificity : Widely expressed with highest levels in lymphoid tissues.
Form : Lyophilised:Reconstitute in sterile 18MOhm/cm water to not less than 100μg/ml, which can then be further diluted to other aqueous solutions.
Purity : >95% by SDS-PAGE
Storage buffer : Preservative: NoneNo additives
Storage : Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Sequences of amino acids : The sequence of the amino acids was determined and was found to be: Lys-Ala-Met-His-Val.
Sequence Similarities : Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Gene Name : CTLA4 cytotoxic T-lymphocyte-associated protein 4 [ Homo sapiens ]
Official Symbol : CTLA4
Synonyms : CTLA4; cytotoxic T-lymphocyte-associated protein 4; celiac disease 3 , CELIAC3; cytotoxic T-lymphocyte protein 4; CD; CD28; CD152; GSE; ICOS;
Gene ID : 1493
mRNA Refseq : NM_001037631
Protein Refseq : NP_001032720
Uniprot ID : P16410
Chromosome Location : 2q33
Pathway : Adaptive Immune System, organism-specific biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; CTLA4 inhibitory signaling, organism-specific biosystem; Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem;
Function : protein binding;

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