Recombinant Human CTSB, His-tagged

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Recombinant Human CTSB, His-tagged

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Cat.No. : CTSB-26410TH
Product Overview : Recombinant fragment, corresponding to amino acids 125-339 of Human Cathepsin B with N terminal His tag; Predicted MWt 25 kDa.
Description : The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the encoded protein, which is a member of the peptidase C1 family, has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene.
Conjugation : HIS
Source : E. coli
Form : Lyophilised:Reconstitute with 60 μl aqua dest.
Storage buffer : Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
Storage : Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids : TNAHVSVEVS AEDLLTCCGS MCGDGCNGGY PAEAWNFWTR KGLVSGGLYE SHVGCRPYSI PPCEHHVNGS RPPCTGEGDT PKCSKICEPG YSPTYKQDKH YGYNSYSVSN SEKDIMAEIY KNGPVEGAFS VYSDFLLYKS GVYQHVTGEM MGGHAIRILG WGVENGTPYW LVANSWNTDW GDNGFFKILR GQDHCGIESE VVAGIPRTDQ YWEKI
Sequence Similarities : Belongs to the peptidase C1 family.
Gene Name : CTSB cathepsin B [ Homo sapiens ]
Official Symbol : CTSB
Synonyms : CTSB; cathepsin B;
Gene ID : 1508
mRNA Refseq : NM_001908
Protein Refseq : NP_001899
MIM : 116810
Uniprot ID : P07858
Chromosome Location : 8p23.1
Pathway : Antigen processing and presentation, organism-specific biosystem; Antigen processing and presentation, conserved biosystem; Lysosome, organism-specific biosystem; Lysosome, conserved biosystem;
Function : cysteine-type endopeptidase activity; kininogen binding; peptidase activity; peptide binding; protein binding;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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