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Native Human CTSS

Cat.No. : CTSS-27405TH
Product Overview : Full length native Human Cathepsin S purified from Human Spleen; amino acids 115-331, 217 amino acids, MWt 24 kDa.
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  • Gene Information
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Description : The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The encoded protein can function as an elastase over a broad pH range in alveolar macrophages. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Biological activity : Activity: Cathepsin S activity detected using Z-Val-Val-Arg-AMC
Form : Lyophilised
Purity : >95% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 100mM Sodium acetate, 1mM EDTA, pH 5.5
Storage : Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Gene Name : CTSS cathepsin S [ Homo sapiens ]
Official Symbol : CTSS
Synonyms : CTSS; cathepsin S;
Gene ID : 1520
mRNA Refseq : NM_001199739
Protein Refseq : NP_001186668
MIM : 116845
Uniprot ID : P25774
Chromosome Location : 1q21
Pathway : Adaptive Immune System, organism-specific biosystem; Antigen processing and presentation, organism-specific biosystem; Antigen processing and presentation, conserved biosystem; Antigen processing-Cross presentation, organism-specific biosystem; Class I MHC mediated antigen processing &
Function : cysteine-type endopeptidase activity; peptidase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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How can the function of CTSS proteins be studied by gene knockout or knockdown techniques? 04/17/2022

The function of CTSS proteins can be studied through gene knockout or knockdown techniques, such as using techniques such as CRISPR-Cas9 or RNAi. These techniques can create cellular models of missing or reduced CTSS proteins to observe their effects on cell death, among other things.

How can I detect the expression level of CTSS protein? 02/05/2022

Expression level of CTSS protein can be detected by immunohistochemistry, western blotting, and real-time quantitative PCR.

How is CTSS protein involved in the process of apoptosis? 10/06/2021

CTSS proteins promote cell death by degrading proteins inside cells. During apoptosis, CTSS proteins degrade key proteins within cells, leading to cell death.

Are the interactions between CTSS proteins and other proteins regulated? 05/04/2021

The interaction between CTSS proteins and other proteins is regulated by the formation of complexes or the regulation of signal transduction pathways. These interactions can be influenced by a variety of factors, such as ion concentrations, neurotransmitters, and growth factors.

What is the relationship between the expression level of CTSS protein and the occurrence and progression of diseases? 02/08/2021

Some studies have shown that the expression level of CTSS protein may be associated with the onset and progression of certain diseases. For example, in some cancers, the expression level of the CTSS protein may change.

In which organelles is CTSS protein expressed? 09/18/2020

It is mainly expressed in lysosomes, which is one of the major proteases in lysosomes.

Customer Reviews (3)

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Reviews
11/01/2021

    High catalytic efficiency, short time, saving time.

    06/13/2021

      The solubility is very good and can be easily dissolved in various buffers.

      03/27/2021

        Anti-pollution ability is very strong, not easy to be polluted.

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