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Recombinant Human CYB5R3, His-tagged

Cat.No.: CYB5R3-27517TH
Product Overview: Recombinant full length soluble form of Human CYB5R3 (amino acids 27-301) fused to His tag at N-terminus, 300 amino acids with a predicted MWt of 34 kDa including the tag.
Description: This gene encodes cytochrome b5 reductase, which includes a membrane-bound form in somatic cells (anchored in the endoplasmic reticulum, mitochondrial and other membranes) and a soluble form in erythrocytes. The membrane-bound form exists mainly on the cytoplasmic side of the endoplasmic reticulum and functions in desaturation and elongation of fatty acids, in cholesterol biosynthesis, and in drug metabolism. The erythrocyte form is located in a soluble fraction of circulating erythrocytes and is involved in methemoglobin reduction. The membrane-bound form has both membrane-binding and catalytic domains, while the soluble form has only the catalytic domain. Alternate splicing results in multiple transcript variants. Mutations in this gene cause methemoglobinemias.
Protein length: 275 amino acids
Conjugation: HIS
Molecular Weight: 34.000kDa inclusive of tags
Source: E. coli
Tissue specificity: Isoform 2 is expressed at late stages of erythroid maturation.
Form: Liquid
Purity: >95% by SDS-PAGE
Storage buffer: pH: 8.00Constituents:0.32% Tris HCl, 0.02% DTT, 10% Glycerol, 0.58% Sodium chloride
Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.
Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MGSHMFQRST PAITLESPDI KYPLRLIDRE IISHDTRRFR FALPSPQHIL GLPVGQHIYL SARIDGNLVV RPYTPISSDD DKGFVDLVIK VYFKDTHPKF PAGGKMSQYL ESMQIGDTIE FRGPSGLLVY QGKGKFAIRP DKKSNPIIRT VKSVGMIAGGTGITPMLQVI RAIMKDPDDH TVCHLLFANQ TEKDILLRPE LEELRNKHSA RFKLWYTLDR APEAWDYGQG FVNEEMIRDH LPPPEEEPLVLMCGPPPMIQ YACLPNLDHV GHPTERCFVF
Sequence Similarities: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.Contains 1 FAD-binding FR-type domain.
Gene Name: CYB5R3 cytochrome b5 reductase 3 [ Homo sapiens ]
Official Symbol: CYB5R3
Synonyms: CYB5R3; cytochrome b5 reductase 3; DIA1, diaphorase (NADH) (cytochrome b 5 reductase); NADH-cytochrome b5 reductase 3;
Gene ID: 1727
mRNA Refseq: NM_000398
Protein Refseq: NP_000389
MIM: 613213
Uniprot ID: P00387
Chromosome Location: 22q13.31-qter
Pathway: Amino sugar and nucleotide sugar metabolism, organism-specific biosystem; Amino sugar and nucleotide sugar metabolism, conserved biosystem; Metabolism, organism-specific biosystem; Metabolism of vitamins and cofactors, organism-specific biosystem; Metabolism of water-soluble vitamins and cofactors, organism-specific biosystem;
Function: FAD binding; cytochrome-b5 reductase activity; oxidoreductase activity;

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