Recombinant Human CYP19A1 CYP19A1-26421TH

Recombinant Human CYP19A1

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Recombinant Human CYP19A1

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Cat.No. : CYP19A1-26421TH
Product Overview : Recombinant fragment corresponding to aa 1-182 of Human Aromatase with proproetary tag. M. Wt. 46.02kDa.
Description : This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. The gene expresses two transcript variants.
Protein length : 182 amino acids
Molecular Weight : 46.020kDa
Source : Wheat germ
Tissue specificity : Brain, placenta and gonads.
Biological activity : useful for Antibody Production and Protein Array
Form : Liquid
Purity : Proprietary Purification
Storage buffer : pH: 8.00Constituents:0.79% Tris HCl, 0.31% GlutathioneNote: Reduced Glutathione
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids : MVLEMLNPIHYNITS IVPEAMPAATMPVLL LTGLFLLVWNYEGTS SIPGPGYCMGIGPLI SHGRFLWMGIGSACN YYNRVYGEFMRVWIS GEETLIISKSSSMFH IMKHNHYSSRFGSKL GLQCIGMHEKGIIFN NNPELWKTTRPFFMK ALSGPGLVRMVTVCA ESLKTHLLLFTPASV N
Sequence Similarities : Belongs to the cytochrome P450 family.
Gene Name : CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 [ Homo sapiens ]
Official Symbol : CYP19A1
Synonyms : CYP19A1; cytochrome P450, family 19, subfamily A, polypeptide 1; CYP19, cytochrome P450, subfamily XIX (aromatization of androgens); cytochrome P450 19A1; ARO; ARO1; aromatase; CPV1; CYAR; P 450AROM;
Gene ID : 1588
mRNA Refseq : NM_000103
Protein Refseq : NP_000094
MIM : 107910
Uniprot ID : P11511
Chromosome Location : 15q21
Pathway : Biological oxidations, organism-specific biosystem; C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone, organism-specific biosystem; C19/C18-Steroid hormone biosynthesis, pregnenolone =>
Function : aromatase activity; electron carrier activity; electron carrier activity; heme binding; heme binding;

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