Recombinant Human DLD, His-tagged

• Cat.No.: DLD-29949TH
• Product Overview: Recombinant full length Human Lipoamide Dehydrogenase fused to His tag at the N-terminus; 511 amino acids with tag, MWt 54.4kDa.

Specification

• Description: This gene encodes the L protein of the mitochondrial glycine cleavage system. The L protein, also named dihydrolipoamide dehydrogenase, is also a component of the pyruvate dehydrogenase complex, the alpha-ketoglutarate dehydrogenase complex, and the branched-chain alpha-keto acide dehydrogenase complex. Mutations in this gene have been identified in patients with E3-deficient maple syrup urine disease and lipoamide dehydrogenase deficiency.
• Conjugation: HIS
• Source: E. coli
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 10% Glycerol, 0.1M Sodium chloride, 20mM Tris HCl, 1mM DTT, pH 8.0
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequence Similarities: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

Gene Information

• Gene Name: DLD dihydrolipoamide dehydrogenase [ Homo sapiens ]
• Official Symbol: DLD
• Synonyms: DLD; dihydrolipoamide dehydrogenase; dihydrolipoamide dehydrogenase (E3 component of pyruvate dehydrogenase complex, 2 oxo glutarate complex, branched chain keto acid dehydrogenase complex) , GCSL, LAD; dihydrolipoyl dehydrogenase, mitochondrial; DLDH; E3
• Gene ID: 1738
• mRNA Refseq: NM_000108
• Protein Refseq: NP_000099
• MIM: 238331
• Uniprot ID: P09622
• Chromosome Location: 7q31-q32
• Pathway: 2-ketoglutarate dehydrogenase complex, conserved biosystem; 2-oxobutanoate degradation I, conserved biosystem; Branched-chain amino acid catabolism, organism-specific biosystem; Citrate cycle (TCA cycle), organism-specific biosystem; Citrate cycle (TCA cycle), conserved biosystem
• Function: NAD binding; dihydrolipoyl dehydrogenase activity; flavin adenine dinucleotide binding; lipoamide binding; oxidoreductase activity