Recombinant Human DMPK

• Cat.No.: DMPK-26934TH
• Product Overview: Recombinant full length Human Dystrophia myotonica protein kinase with N-terminal proprietary tag expressed in a Baculovirus infected Sf9 cell expression system, MWt 105kDa.

Specification

• Description: The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3 untranslated region of this gene contains 5-37 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
• Biological activity: The Specific activity of DMPK-26934TH was determined to be 4.5 nmol/min/mg.
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.

Gene Information

• Gene Name: DMPK dystrophia myotonica-protein kinase [ Homo sapiens ]
• Official Symbol: DMPK
• Synonyms: DMPK; dystrophia myotonica-protein kinase; myotonin-protein kinase; DM; DM protein kinase; DM1; DM1PK; DMK; dystrophia myotonica 1; MDPK; MT PK; myotonic dystrophy associated protein kinase; myotonin protein kinase A; thymopoietin homolog
• Gene ID: 1760
• mRNA Refseq: NM_001081560
• Protein Refseq: NP_001075029
• MIM: 605377
• Uniprot ID: Q09013
• Chromosome Location: 19q13.3
• Function: ATP binding; metal ion binding; myosin phosphatase regulator activity; nucleotide binding; protein binding