Recombinant Human EDNRB EDNRB-28559TH

Recombinant Human EDNRB

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Recombinant Human EDNRB

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Cat.No. : EDNRB-28559TH
Product Overview : Recombinant fragment of Human Endothelin B Receptor with a N terminal proprietary tag: predicted molecular weight 33.88 kDa.
Description : The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Protein length : 75 amino acids
Molecular Weight : 33.880kDa inclusive of tags
Source : Wheat germ
Tissue specificity : Expressed in placental stem villi vessels, but not in cultured placental villi smooth muscle cells.
Form : Liquid
Purity : Proprietary Purification
Storage buffer : pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids : EERGFPPDRATPLLQ TAEIMTPPTKTLWPK GSNASLARSLAPAEV PKGDRTAGSPPRTIS PPPCQGPIEIKETFK
Sequence Similarities : Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily.
Gene Name : EDNRB endothelin receptor type B [ Homo sapiens ]
Official Symbol : EDNRB
Synonyms : EDNRB; endothelin receptor type B; HSCR, HSCR2; endothelin B receptor; ETB;
Gene ID : 1910
mRNA Refseq : NM_000115
Protein Refseq : NP_000106
MIM : 131244
Uniprot ID : P24530
Chromosome Location : 13q22
Pathway : Arf6 trafficking events, organism-specific biosystem; Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Endothelins, organism-specific biosystem;
Function : G-protein coupled receptor activity; endothelin receptor activity; endothelin receptor activity; endothelin receptor activity; peptide hormone binding;

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