Recombinant Human EFEMP1

• Cat.No.: EFEMP1-27780TH
• Product Overview: Recombinant full length Human EFEMP1 with N terminal proprietary tag, 79.97kDa.

Specification

• Description: This gene encodes a member of the fibulin family of extracellular matrix glycoproteins. Like all members of this family, the encoded protein contains tandemly repeated epidermal growth factor-like repeats followed by a C-terminus fibulin-type domain. This gene is upregulated in malignant gliomas and may play a role in the aggressive nature of these tumors. Mutations in this gene are associated with Doyne honeycomb retinal dystrophy. Alternatively spliced transcript variants that encode the same protein have been described.
• Protein length: 493 amino acids
• Molecular Weight: 79.970kDa inclusive of tags
• Source: Wheat germ
• Tissue specificity: In the eye, associated with photoreceptor outer and inner segment regions, the nerve fiber layer, outer nuclear layer and inner and outer plexiform layers of the retina.
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MLKALFLTMLTLALVKSQDTEETITYTQCTDGYEWDPVGQ QCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVN NEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVA SAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCA AGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQ CPPGYQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCS PGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCN QGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMC PQGYQVVRSRTCQDINECETTNECREDEMCWNYHGGFRCY PRNPCQDPYILTPENRCVCPVSNAMCRELPQSIVYKYMSI RSDRSVPSDIFQIQATTIYANTINTFRIKSGSENGEFYLR QTSPVSAMLVLVKSLSGPREHIVDLEMLTASSIGTFRTSS VLRLTIIVGPFSF
• Sequence Similarities: Belongs to the fibulin family.Contains 6 EGF-like domains.

Gene Information

• Gene Name: EFEMP1 EGF containing fibulin-like extracellular matrix protein 1 [ Homo sapiens ]
• Official Symbol: EFEMP1
• Synonyms: EFEMP1; EGF containing fibulin-like extracellular matrix protein 1; DHRD, EGF containing fibulin like extracellular matrix protein 1 , FBNL, fibrillin like; EGF-containing fibulin-like extracellular matrix protein 1; FBLN3; fibulin 3; MTLV; S1 5
• Gene ID: 2202
• mRNA Refseq: NM_001039348
• Protein Refseq: NP_001034437
• MIM: 601548
• Uniprot ID: Q12805
• Chromosome Location: 2p16
• Function: calcium ion binding; epidermal growth factor receptor binding; epidermal growth factor-activated receptor activity; growth factor activity; protein binding