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Recombinant Human EFNA1, His-tagged

Cat.No. : EFNA1-28470TH
Product Overview : Recombinant full length Human Ephrin A1 with an N terminal His tag; 185 amino acids with tag, Predicted MWt 21.6 kDa.
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Description : This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin which binds to the EPHA2, EPHA4, EPHA5, EPHA6, and EPHA7 receptors. Two transcript variants that encode different isoforms were identified through sequence analysis.
Protein length : 164 amino acids
Conjugation : HIS
Molecular Weight : 21.600kDa inclusive of tags
Source : E. coli
Tissue specificity : Brain. Down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells (at protein level).
Form : Liquid
Purity : >90% by SDS-PAGE
Storage buffer : pH: 8.00Constituents:0.32% Tris HCl, 10% Glycerol, 2.4% Urea
Storage : Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids : MGSSHHHHHHSSGLVPRGSHMDRHT VFWNSSNPKFRNEDYTIHVQLNDYV DIICPHYEDHSVADAAMEQYILYLV EHEEYQLCQPQSKDQVRWQCNRPSA KHGPEKLSEKFQRFTPFTLGKEFKE GHSYYYISKPIHQHEDRCLRLKVTV SGKITHSPQAHVNPQEKRLAADDPE VRVLHSIGHS
Sequence Similarities : Belongs to the ephrin family.
Gene Name : EFNA1 ephrin-A1 [ Homo sapiens ]
Official Symbol : EFNA1
Synonyms : EFNA1; ephrin-A1; EPLG1, TNFAIP4; ECKLG; LERK1;
Gene ID : 1942
mRNA Refseq : NM_182685
Protein Refseq : NP_872626
MIM : 191164
Uniprot ID : P20827
Chromosome Location : 1q21-q22
Pathway : Arf6 signaling events, organism-specific biosystem; Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; EPHA forward signaling, organism-specific biosystem; EPHA2 forward signaling, organism-specific biosystem;
Function : ephrin receptor binding; protein binding; receptor binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can EFNA1 be a target for therapeutic interventions in cancer treatment? 05/06/2021

Yes, EFNA1 is being investigated as a potential therapeutic target in cancer treatment, aiming to develop drugs that modulate its activity.

Are there diagnostic applications for EFNA1 in cancer detection? 01/15/2021

Researchers are exploring the use of EFNA1 as a biomarker for cancer detection, with studies suggesting its potential as a diagnostic tool.

How does EFNA1 interact with the Eph receptors, and what is the significance of this interaction? 04/16/2019

EFNA1 binds to Eph receptors, initiating cell signaling pathways that regulate various cellular processes, making this interaction crucial for normal physiological functions.

How does EFNA1 impact cancer research and treatment? 02/02/2018

EFNA1 is implicated in cancer progression, influencing cell migration and invasion. Understanding its role can potentially lead to targeted therapies for certain cancers.

Are there any neurological disorders associated with EFNA1 dysregulation? 10/26/2016

Dysregulation of EFNA1 has been linked to certain neurological disorders, including Alzheimer's disease and neurodevelopmental disorders.

Customer Reviews (3)

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Reviews
08/15/2019

    Their prompt assistance and willingness to go above and beyond to ensure my success have been immensely valuable.

    04/04/2019

      Its purity, stability, and consistency are unparalleled, ensuring reliable and reproducible results in my research.

      11/22/2016

        This protein has proven to be an invaluable asset in my experiments, enabling accurate and precise measurements with exceptional sensitivity.

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