Recombinant Human EFNA1, His-tagged
Cat.No. : | EFNA1-28470TH |
Product Overview : | Recombinant full length Human Ephrin A1 with an N terminal His tag; 185 amino acids with tag, Predicted MWt 21.6 kDa. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin which binds to the EPHA2, EPHA4, EPHA5, EPHA6, and EPHA7 receptors. Two transcript variants that encode different isoforms were identified through sequence analysis. |
Protein length : | 164 amino acids |
Conjugation : | HIS |
Molecular Weight : | 21.600kDa inclusive of tags |
Source : | E. coli |
Tissue specificity : | Brain. Down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells (at protein level). |
Form : | Liquid |
Purity : | >90% by SDS-PAGE |
Storage buffer : | pH: 8.00Constituents:0.32% Tris HCl, 10% Glycerol, 2.4% Urea |
Storage : | Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. |
Sequences of amino acids : | MGSSHHHHHHSSGLVPRGSHMDRHT VFWNSSNPKFRNEDYTIHVQLNDYV DIICPHYEDHSVADAAMEQYILYLV EHEEYQLCQPQSKDQVRWQCNRPSA KHGPEKLSEKFQRFTPFTLGKEFKE GHSYYYISKPIHQHEDRCLRLKVTV SGKITHSPQAHVNPQEKRLAADDPE VRVLHSIGHS |
Sequence Similarities : | Belongs to the ephrin family. |
Gene Name : | EFNA1 ephrin-A1 [ Homo sapiens ] |
Official Symbol : | EFNA1 |
Synonyms : | EFNA1; ephrin-A1; EPLG1, TNFAIP4; ECKLG; LERK1; |
Gene ID : | 1942 |
mRNA Refseq : | NM_182685 |
Protein Refseq : | NP_872626 |
MIM : | 191164 |
Uniprot ID : | P20827 |
Chromosome Location : | 1q21-q22 |
Pathway : | Arf6 signaling events, organism-specific biosystem; Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; EPHA forward signaling, organism-specific biosystem; EPHA2 forward signaling, organism-specific biosystem; |
Function : | ephrin receptor binding; protein binding; receptor binding; |
Products Types
◆ Recombinant Protein | ||
Efna1-159M | Recombinant Mouse Efna1 Protein, His (Fc)-Avi-tagged | +Inquiry |
Efna1-3264M | Active Recombinant Mouse Efna1 protein(Met1-Ser182), hFc-tagged | +Inquiry |
EFNA1-229H | Recombinant Human EFNA1 Protein, Fc-tagged | +Inquiry |
EFNA1-1386H | Recombinant Human EFNA1 Protein, MYC/DDK-tagged | +Inquiry |
EFNA1-1382M | Recombinant Mouse EFNA1 Protein, Fc/His-tagged | +Inquiry |
◆ Lysates | ||
EFNA1-2177MCL | Recombinant Mouse EFNA1 cell lysate | +Inquiry |
EFNA1-2594HCL | Recombinant Human EFNA1 cell lysate | +Inquiry |
EFNA1-1514RCL | Recombinant Rat EFNA1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionYes, EFNA1 is being investigated as a potential therapeutic target in cancer treatment, aiming to develop drugs that modulate its activity.
Researchers are exploring the use of EFNA1 as a biomarker for cancer detection, with studies suggesting its potential as a diagnostic tool.
EFNA1 binds to Eph receptors, initiating cell signaling pathways that regulate various cellular processes, making this interaction crucial for normal physiological functions.
EFNA1 is implicated in cancer progression, influencing cell migration and invasion. Understanding its role can potentially lead to targeted therapies for certain cancers.
Dysregulation of EFNA1 has been linked to certain neurological disorders, including Alzheimer's disease and neurodevelopmental disorders.
Customer Reviews (3)
Write a reviewTheir prompt assistance and willingness to go above and beyond to ensure my success have been immensely valuable.
Its purity, stability, and consistency are unparalleled, ensuring reliable and reproducible results in my research.
This protein has proven to be an invaluable asset in my experiments, enabling accurate and precise measurements with exceptional sensitivity.
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