Recombinant Human ENG

• Cat.No.: ENG-26364TH
• Product Overview: Recombinant fragment, corresponding to amino acids 1-586 of Human CD105, expressed in Insect cells.

Specification

• Description: This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds TGFB1 and TGFB3 with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Tissue specificity: Endoglin is restricted to endothelial cells in all tissues except bone marrow.
• Form: Lyophilised:The carrier-free protein should be used immediately upon reconstitution to avoid losses in activity due to non-specific binding to the inside surface of the vial. For long term storage as a dilute solution, a carrier protein (e.g. 0.1% HSA or
• Purity: >95% by SDS-PAGE
• Storage buffer: None
• Storage: Please see Notes section

Gene Information

• Gene Name: ENG endoglin [ Homo sapiens ]
• Official Symbol: ENG
• Synonyms: ENG; endoglin; ORW, ORW1, Osler Rendu Weber syndrome 1; CD105; END; HHT1
• Gene ID: 2022
• mRNA Refseq: NM_000118
• Protein Refseq: NP_000109
• MIM: 131195
• Uniprot ID: P17813
• Chromosome Location: 9q33-q34.1
• Pathway: HIF-1-alpha transcription factor network, organism-specific biosystem; TGF Beta Signaling Pathway, organism-specific biosystem; TGF-beta Receptor Signaling Pathway, organism-specific biosystem
• Function: activin binding; galactose binding; glycosaminoglycan binding; glycosaminoglycan binding; protein binding