Recombinant Human ENG

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Recombinant Human ENG

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Cat.No. : ENG-26364TH
Product Overview : Recombinant fragment, corresponding to amino acids 1-586 of Human CD105, expressed in Insect cells.
Description : This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds TGFB1 and TGFB3 with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Tissue specificity : Endoglin is restricted to endothelial cells in all tissues except bone marrow.
Form : Lyophilised:The carrier-free protein should be used immediately upon reconstitution to avoid losses in activity due to non-specific binding to the inside surface of the vial. For long term storage as a dilute solution, a carrier protein (e.g. 0.1% HSA or
Purity : >95% by SDS-PAGE
Storage buffer : None
Storage : Please see Notes section
Gene Name : ENG endoglin [ Homo sapiens ]
Official Symbol : ENG
Synonyms : ENG; endoglin; ORW, ORW1, Osler Rendu Weber syndrome 1; CD105; END; HHT1;
Gene ID : 2022
mRNA Refseq : NM_000118
Protein Refseq : NP_000109
MIM : 131195
Uniprot ID : P17813
Chromosome Location : 9q33-q34.1
Pathway : HIF-1-alpha transcription factor network, organism-specific biosystem; TGF Beta Signaling Pathway, organism-specific biosystem; TGF-beta Receptor Signaling Pathway, organism-specific biosystem;
Function : activin binding; galactose binding; glycosaminoglycan binding; glycosaminoglycan binding; protein binding;

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