Recombinant Human F7
Cat.No. : | F7-28711TH |
Product Overview : | Human Recombinant Full length Factor VIIa produced in BHK is a glycosylated polypeptide two-chain dimer consisting of 406 amino acids with a molecular weight of 50kD. |
- Specification
- Gene Information
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Description : | This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Alternative splicing of this gene results in 2 transcripts. Defects in this gene can cause coagulopathy. |
Biological activity : | Biological Activity: The potency per mg was tested and found to be 50,000Units/mg. |
Form : | Lyophilised:It is recommended to reconstitute the lyophilized Factor-VIIa in sterile 18MO-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. |
Purity : | >95% by SDS-PAGE |
Storage buffer : | Preservative: NoneConstituents: 50mg/ml Mannitol, 4.86mg/ml Sodium chloride dihydrate, 2.45mg/ml Calcium chloride, 116μg/ml Tween 80 |
Storage : | Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. |
Gene Name : | F7 coagulation factor VII (serum prothrombin conversion accelerator) [ Homo sapiens ] |
Official Symbol : | F7 |
Synonyms : | F7; coagulation factor VII (serum prothrombin conversion accelerator); coagulation factor VII; eptacog alfa; factor VII; FVII coagulation protein; |
Gene ID : | 2155 |
mRNA Refseq : | NM_000131 |
Protein Refseq : | NP_000122 |
MIM : | 613878 |
Uniprot ID : | P08709 |
Chromosome Location : | 13q34 |
Pathway : | BMAL1:CLOCK/NPAS2 Activates Gene Expression, organism-specific biosystem; Blood Clotting Cascade, organism-specific biosystem; Circadian Clock, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; |
Function : | calcium ion binding; glycoprotein binding; peptidase activity; receptor binding; serine-type endopeptidase activity; |
Products Types
◆ Recombinant Protein | ||
F7-2893H | Recombinant Human F7 Protein, His (Fc)-Avi-tagged | +Inquiry |
F7-1837R | Recombinant Rat F7 Protein, His (Fc)-Avi-tagged | +Inquiry |
F7-2206M | Active Recombinant Mouse F7 protein(Met1-Leu446), His-tagged | +Inquiry |
F7-959H | Recombinant Human F7 Protein, MYC/DDK-tagged | +Inquiry |
F7-3622H | Recombinant Human F7 Protein, GST-tagged | +Inquiry |
◆ Native Protein | ||
F7-5303H | Native Human Coagulation Factor VII (serum prothrombin conversion accelerator) | +Inquiry |
◆ Lysates | ||
F7-1973HCL | Recombinant Human F7 cell lysate | +Inquiry |
F7-001MCL | Recombinant Mouse F7 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionFactor VII's role in the coagulation cascade ensures rapid initiation of clot formation, preventing excessive bleeding and contributing to hemostasis.
Factor VII is a key player in the extrinsic pathway, where it forms a complex with tissue factor to activate factor X, initiating the cascade leading to thrombin generation.
Factor VII is activated through a proteolytic cleavage, converting it into its active form (VIIa). This activation is regulated by tissue factor and other coagulation factors.
F7 deficiency results in impaired blood clotting, leading to a bleeding disorder known as coagulation factor VII deficiency. This condition can manifest in varying degrees of severity.
Factor VII is activated to its enzymatically active form (factor VIIa) and initiates the coagulation cascade by activating factor X, ultimately leading to the formation of a stable blood clot.
Customer Reviews (3)
Write a reviewQuick turnaround—this product arrived swiftly, facilitating our research.
Exceptional quality and precision—our lab relies on this protein consistently.
Invaluable assistance from customer service—professional and responsive.
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