Recombinant Human F7 F7-28711TH

Recombinant Human F7

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Recombinant Human F7

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Cat.No. : F7-28711TH
Product Overview : Human Recombinant Full length Factor VIIa produced in BHK is a glycosylated polypeptide two-chain dimer consisting of 406 amino acids with a molecular weight of 50kD.
Description : This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Alternative splicing of this gene results in 2 transcripts. Defects in this gene can cause coagulopathy.
Biological activity : Biological Activity: The potency per mg was tested and found to be 50,000Units/mg.
Form : Lyophilised:It is recommended to reconstitute the lyophilized Factor-VIIa in sterile 18MO-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions.
Purity : >95% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 50mg/ml Mannitol, 4.86mg/ml Sodium chloride dihydrate, 2.45mg/ml Calcium chloride, 116μg/ml Tween 80
Storage : Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Gene Name : F7 coagulation factor VII (serum prothrombin conversion accelerator) [ Homo sapiens ]
Official Symbol : F7
Synonyms : F7; coagulation factor VII (serum prothrombin conversion accelerator); coagulation factor VII; eptacog alfa; factor VII; FVII coagulation protein;
Gene ID : 2155
mRNA Refseq : NM_000131
Protein Refseq : NP_000122
MIM : 613878
Uniprot ID : P08709
Chromosome Location : 13q34
Pathway : BMAL1:CLOCK/NPAS2 Activates Gene Expression, organism-specific biosystem; Blood Clotting Cascade, organism-specific biosystem; Circadian Clock, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem;
Function : calcium ion binding; glycoprotein binding; peptidase activity; receptor binding; serine-type endopeptidase activity;

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