Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human F7

Cat.No. : F7-28711TH
Product Overview : Human Recombinant Full length Factor VIIa produced in BHK is a glycosylated polypeptide two-chain dimer consisting of 406 amino acids with a molecular weight of 50kD.
  • Specification
  • Gene Information
  • Related Products
Description : This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Alternative splicing of this gene results in 2 transcripts. Defects in this gene can cause coagulopathy.
Biological activity : Biological Activity: The potency per mg was tested and found to be 50,000Units/mg.
Form : Lyophilised:It is recommended to reconstitute the lyophilized Factor-VIIa in sterile 18MO-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions.
Purity : >95% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 50mg/ml Mannitol, 4.86mg/ml Sodium chloride dihydrate, 2.45mg/ml Calcium chloride, 116μg/ml Tween 80
Storage : Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Gene Name : F7 coagulation factor VII (serum prothrombin conversion accelerator) [ Homo sapiens ]
Official Symbol : F7
Synonyms : F7; coagulation factor VII (serum prothrombin conversion accelerator); coagulation factor VII; eptacog alfa; factor VII; FVII coagulation protein;
Gene ID : 2155
mRNA Refseq : NM_000131
Protein Refseq : NP_000122
MIM : 613878
Uniprot ID : P08709
Chromosome Location : 13q34
Pathway : BMAL1:CLOCK/NPAS2 Activates Gene Expression, organism-specific biosystem; Blood Clotting Cascade, organism-specific biosystem; Circadian Clock, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem;
Function : calcium ion binding; glycoprotein binding; peptidase activity; receptor binding; serine-type endopeptidase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (5)

Ask a question
How does F7 contribute to hemostasis, and what is its role in preventing excessive bleeding? 04/02/2021

Factor VII's role in the coagulation cascade ensures rapid initiation of clot formation, preventing excessive bleeding and contributing to hemostasis.

Discuss the role of F7 in the extrinsic pathway of blood coagulation. 07/20/2020

Factor VII is a key player in the extrinsic pathway, where it forms a complex with tissue factor to activate factor X, initiating the cascade leading to thrombin generation.

What are the mechanisms of F7 activation, and how is it regulated at the molecular level? 01/15/2019

Factor VII is activated through a proteolytic cleavage, converting it into its active form (VIIa). This activation is regulated by tissue factor and other coagulation factors.

Explain the biochemical basis of F7 deficiency and its implications for bleeding disorders. 11/05/2018

F7 deficiency results in impaired blood clotting, leading to a bleeding disorder known as coagulation factor VII deficiency. This condition can manifest in varying degrees of severity.

Explain the role of F7 in the coagulation cascade and blood clot formation. 09/28/2018

Factor VII is activated to its enzymatically active form (factor VIIa) and initiates the coagulation cascade by activating factor X, ultimately leading to the formation of a stable blood clot.

Customer Reviews (3)

Write a review
Reviews
05/18/2022

    Quick turnaround—this product arrived swiftly, facilitating our research.

    10/03/2019

      Exceptional quality and precision—our lab relies on this protein consistently.

      05/29/2018

        Invaluable assistance from customer service—professional and responsive.

        Ask a Question for All F7 Products

        Required fields are marked with *

        My Review for All F7 Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends