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Recombinant Human CD226 Molecule

Cat. No.: CD226-1603H
Description: DNAX accessory molecule 1 (DNAM-1), is a tyrosine-phosphorylated signal-transducing molecule belonging to the immunoglobulin superfamily and participates in primary adhesion during cytotoxic T lymphocyte-mediated cytotoxicity. DNAM-1 is a functional glycoprotein expressed on immune cells, such as natural killer and T-cells. It is activated upon interaction with its biological ligands, the poliovirus receptor and nectin-2. Signaling cascades involving stimulation of DNAM-1 lead to various biological responses, including target cell lysis and immune cell activation. DNAM-1 appears to be an integral molecule in immune responses in cancer, allergic inflammatory disorders and autoimmune diseases.
Molecular Weight: The predicted molecular weight of Recombinant Human DNAM-1 is Mr 53 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 90 kDa.
Source: NSO Cells.
State Of Matter: Lyophilized.
Purity: >95% by SDS Page and analyzed by silver stain.
Endotoxin: <0.1 ng per 1 µg as determined by the LAL method.
Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Gene Name: CD226 CD226 molecule [ Homo sapiens ]
Synonyms: CD226; CD226 molecule; PTA1; DNAM1; DNAM-1; TLiSA1; CD226 antigen; adhesion glycoprotein; DNAX accessory molecule-1; platelet and T cell activation antigen 1; T lineage-specific activation antigen 1 antigen
Gene ID: 10666
mRNA Refseq: NM_006566
Protein Refseq: NP_006557
MIM: 605397
UniProt ID: Q15762
Chromosome Location: 18q22
Pathway: adhesion molecules (CAMs)
Function: cell adhesion molecule binding; integrin binding; protein kinase binding; receptor activity

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