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Recombinant Human FBLN1

Cat.No. : FBLN1-28904TH
Product Overview : Recombinant full length Human Fibulin 1 with N terminal proprietary tag; Predicted MWt 101.2 kDa inclusive of tag.
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Description : Fibulin 1 is a secreted glycoprotein that becomes incorporated into a fibrillar extracellular matrix. Calcium-binding is apparently required to mediate its binding to laminin and nidogen. It mediates platelet adhesion via binding fibrinogen. Four splice variants which differ in the 3 end have been identified. Each variant encodes a different isoform, but no functional distinctions have been identified among the four variants.
Protein length : 683 amino acids
Molecular Weight : 101.200kDa inclusive of tags
Source : Wheat germ
Tissue specificity : Isoform A and isoform B are only expressed in placenta. Isoform C and isoform D are expressed in a variety of tissues and cultured cells.
Form : Liquid
Purity : Proprietary Purification
Storage buffer : pH: 8.00Constituents:0.79% Tris HCl, 0.3% Glutathione
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids : MERAAPSRRVPLQLLLLGGLALLAAGVDADVLLEACCADG HRMATHQKDCSLPYATESKECRMVQEQCCHSQLEELHCAT GISLANEQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQ AQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQE TDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCS CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSF RCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQ NTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCP IGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC APPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDV NECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCE DINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCE DIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNG SNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENY RRSAATRCERLPCHENRECSKLPLRITYYHLSFPTNIQAP AVVFRMGPSSAVPGDSMQLAITGGNEEGFFTTRKVSPHSG VVALTKPVPEPRDLLLTVKMDLSRHGTVSSFVAKLFIFVS AEL
Sequence Similarities : Belongs to the fibulin family.Contains 3 anaphylatoxin-like domains.Contains 9 EGF-like domains.
Gene Name : FBLN1 fibulin 1 [ Homo sapiens ]
Official Symbol : FBLN1
Synonyms : FBLN1; fibulin 1; fibulin-1; FBLN;
Gene ID : 2192
mRNA Refseq : NM_001996
Protein Refseq : NP_001987
MIM : 135820
Uniprot ID : P23142
Chromosome Location : 22q13.31
Function : calcium ion binding; extracellular matrix structural constituent; peptidase activator activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any therapeutic implications of FBLN1 in cardiovascular diseases? 07/26/2022

FBLN1 has been identified as a potential therapeutic target for the treatment of cardiovascular diseases due to its involvement in vascular function.

Can FBLN1 be used for genetic testing in connective tissue disorders? 05/21/2021

Genetic testing for FBLN1 mutations can be helpful in diagnosing certain connective tissue disorders.

Are there any known side effects of targeting FBLN1 for therapeutic purposes? 05/07/2021

The potential side effects of targeting FBLN1 as a therapeutic target are still under investigation and require further clinical trials.

How does FBLN1 compare to other proteins in its clinical applications? 01/17/2018

FBLN1 has distinct roles and implications in clinical applications compared to other proteins, making it an important focus of research.

How is FBLN1 related to connective tissue disorders? 08/28/2017

Mutations in the FBLN1 gene have been associated with developmental abnormalities in connective tissues, leading to connective tissue disorders such as Marfan syndrome and cutis laxa.

Customer Reviews (3)

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Reviews
06/23/2017

    This partnership enhances research productivity while ensuring accurate and meaningful outcomes.

    07/27/2016

      The manufacturer's commitment to maintaining stringent quality control measures guarantees that I can trust the protein's integrity and reliability throughout my experiments.

      02/29/2016

        Its purity and stability ensure consistent and accurate results, making it an ideal tool for my research endeavors.

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