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Recombinant Human FBLN1

Cat.No. : FBLN1-28904TH
Product Overview : Recombinant full length Human Fibulin 1 with N terminal proprietary tag; Predicted MWt 101.2 kDa inclusive of tag.
Description : Fibulin 1 is a secreted glycoprotein that becomes incorporated into a fibrillar extracellular matrix. Calcium-binding is apparently required to mediate its binding to laminin and nidogen. It mediates platelet adhesion via binding fibrinogen. Four splice variants which differ in the 3 end have been identified. Each variant encodes a different isoform, but no functional distinctions have been identified among the four variants.
Protein length : 683 amino acids
Molecular Weight : 101.200kDa inclusive of tags
Source : Wheat germ
Tissue specificity : Isoform A and isoform B are only expressed in placenta. Isoform C and isoform D are expressed in a variety of tissues and cultured cells.
Form : Liquid
Purity : Proprietary Purification
Storage buffer : pH: 8.00Constituents:0.79% Tris HCl, 0.3% Glutathione
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids : MERAAPSRRVPLQLLLLGGLALLAAGVDADVLLEACCADG HRMATHQKDCSLPYATESKECRMVQEQCCHSQLEELHCAT GISLANEQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQ AQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQE TDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCS CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSF RCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQ NTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCP IGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC APPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDV NECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCE DINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCE DIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNG SNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENY RRSAATRCERLPCHENRECSKLPLRITYYHLSFPTNIQAP AVVFRMGPSSAVPGDSMQLAITGGNEEGFFTTRKVSPHSG VVALTKPVPEPRDLLLTVKMDLSRHGTVSSFVAKLFIFVS AEL
Sequence Similarities : Belongs to the fibulin family.Contains 3 anaphylatoxin-like domains.Contains 9 EGF-like domains.
Gene Name : FBLN1 fibulin 1 [ Homo sapiens ]
Official Symbol : FBLN1
Synonyms : FBLN1; fibulin 1; fibulin-1; FBLN;
Gene ID : 2192
mRNA Refseq : NM_001996
Protein Refseq : NP_001987
MIM : 135820
Uniprot ID : P23142
Chromosome Location : 22q13.31
Function : calcium ion binding; extracellular matrix structural constituent; peptidase activator activity;

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