Recombinant Human FOXO1, His-tagged

• Cat.No.: FOXO1-28946TH
• Product Overview: Recombinant fragment, corresponding to amino acids 277-655 of Human FOXO1A with N terminal His tag; 379 amino acids, 49kDa.

Specification

• Description: This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain.The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma.
• Conjugation: HIS
• Source: E. coli
• Tissue specificity: Ubiquitous.
• Form: Lyophilised:Reconstitute with 151 μl aqua dest.
• Storage buffer: Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: LQSGQEGAGDSPGSQFSKWPASPGSHSNDDFDNWSTFRPR TSSNASTISGRLSPIMTEQDDLGEGDVHSMVYPPSAAK MASTLPSLSEISNPENMENLLDNLNLLSSPTSLTVSTQSS PGTMMQQTPCYSFAPPNTSLNSPSPNYQKYTYGQSSMS PLPQMPIQTLQDNKSSYGGMSQYNCAPGLLKELLTSDS PPHNDIMTPVDPGVAQPNSRVLGQNVMMGPNSVMSTYGSQ ASHNKMMNPSSHTHPGHAQQTSAVNGRPLPHTVSTMPH TSGMNRLTQVKTPVQVPLPHPMQMSALGGYSSVSSCNG YGRMGLLHQEKLPSDLDGMFIERLDCDMESIIRNDLMDGD TLDFNFDNVLPNQSFPHSVKTTTHSWVSG
• Sequence Similarities: Contains 1 fork-head DNA-binding domain.

Gene Information

• Gene Name: FOXO1 forkhead box O1 [ Homo sapiens ]
• Official Symbol: FOXO1
• Synonyms: FOXO1; forkhead box O1; FKHR, forkhead homolog in rhabdomyosarcoma , FOXO1A; forkhead box protein O1; FKH1
• Gene ID: 2308
• mRNA Refseq: NM_002015
• Protein Refseq: NP_002006
• MIM: 136533
• Uniprot ID: Q12778
• Chromosome Location: 13q14.1
• Pathway: AKT phosphorylates targets in the nucleus, organism-specific biosystem; AKT-mediated inactivation of FOXO1A, organism-specific biosystem; Adipogenesis, organism-specific biosystem; Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem
• Function: DNA bending activity; double-stranded DNA binding; protein binding; protein kinase binding; sequence-specific DNA binding