Recombinant Human FRS2

• Cat.No.: FRS2-28951TH
• Product Overview: Recombinant fragment corresponding to amino acids 1-341 of Human FRS2 with a propreitary tag; predicted mwt: 63.14 kDa.

Specification

• Description: Fibroblast growth factor receptor substrate 2 is a protein that in humans is encoded by the FRS2 gene.
• Protein length: 341 amino acids
• Molecular Weight: 63.140kDa inclusive of tags
• Source: Wheat germ
• Tissue specificity: Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.79% Tris HCl, 0.31% GlutathioneNote: Glutathione is reduced.
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MGSCCSCPDKDTVPDNHRNKFKVIN VDDDGNELGSGIMELTDTELILYTR KRDSVKWHYLCLRRYGYDSNLFSFE SGRRCQTGQGIFAFKCARAEELFNM LQEIMQNNSINVVEEPVVERNNHQT ELEVPRTPRTPTTPGFAAQNLPNGY PRYPSFGDASSHPSSRHPSVGSARL PSVGEESTHPLLVAEEQVHTYVNTT GVQEERKNRTSVHVPLEARVSNAES STPKEEPSSIEDRDPQILLEPEGVK FVLGPTPVQKQLMEKEKLEQLGRDQ VSGSGANNTEWDTGYDSDERRDAPS VNKLVYENINGLSIPSASGVRRGRL TSTSTSDTQNINNSAQ
• Sequence Similarities: Contains 1 IRS-type PTB domain.

Gene Information

• Gene Name: FRS2 fibroblast growth factor receptor substrate 2 [ Homo sapiens ]
• Official Symbol: FRS2
• Synonyms: FRS2; fibroblast growth factor receptor substrate 2; FRS2A; FRS2alpha; SNT 1; SNT1
• Gene ID: 10818
• mRNA Refseq: NM_001042555
• Protein Refseq: NP_001036020
• MIM: 607743
• Uniprot ID: Q8WU20
• Chromosome Location: 12q15
• Pathway: Downstream signaling of activated FGFR, organism-specific biosystem; FGF signaling pathway, organism-specific biosystem; FRS2-mediated cascade, organism-specific biosystem; Frs2-mediated activation, organism-specific biosystem; IRS-mediated signalling, organism-specific biosystem
• Function: fibroblast growth factor receptor binding; insulin receptor binding; phosphatase activator activity; protein binding; transmembrane receptor protein tyrosine kinase adaptor activity