"GCLC" Related Products


Recombinant Human GCLC

Cat.No.: GCLC-28159TH
Product Overview: Recombinant full length Human GCLC with a proprietary tag; Predicted MWt 96.14.
Description: Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.
Protein length: 637 amino acids
Molecular Weight: 96.140kDa inclusive of tags
Source: Wheat germ
Biological activity: useful for Antibody Production and Protein Array
Form: Liquid
Purity: Proprietary Purification
Storage buffer: pH: 8.00Constituents:0.79% Tris HCl, 0.31% GlutathioneNote: Glutathione is reduced
Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities: Belongs to the glutamate--cysteine ligase type 3 family.
Gene Name: GCLC glutamate-cysteine ligase, catalytic subunit [ Homo sapiens ]
Official Symbol: GCLC
Synonyms: GCLC; glutamate-cysteine ligase, catalytic subunit; GLCL, GLCLC; glutamate--cysteine ligase catalytic subunit; GCS;
Gene ID: 2729
mRNA Refseq: NM_001197115
Protein Refseq: NP_001184044
MIM: 606857
Uniprot ID: P48506
Chromosome Location: 6p12
Pathway: Biological oxidations, organism-specific biosystem; Glutathione biosynthesis, glutamate => glutathione, organism-specific biosystem; Glutathione biosynthesis, glutamate => glutathione, conserved biosystem;
Function: ADP binding; ATP binding; coenzyme binding; glutamate binding; glutamate-cysteine ligase activity;

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